Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 269.00 | |
5 mg | In stock | $ 666.00 | |
10 mg | In stock | $ 948.00 | |
25 mg | In stock | $ 1,420.00 | |
50 mg | In stock | $ 1,890.00 | |
100 mg | In stock | $ 2,570.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 783.00 |
Description | SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM. |
Targets&IC50 | SETDB1-TTD:88 nM(Kd) |
In vitro | SETDB1-TTD-IN-1, at concentrations ranging from 2.5 to 40 μM, effectively stabilizes the SETDB1-TTD protein in a dose-dependent manner within HEK293T cells. Similarly, at these concentrations over a 24-hour period, it notably alters the expression of 72 genes in THP-1 cells, a human acute monocytic leukemia cell line. Additionally, SETDB1-TTD-IN-1 demonstrates binding affinity to 53BP1 and JMJD2A proteins, with dissociation constants (Kds) of 4.3 μM and 86 μM, respectively. However, it lacks activity against 14 out of 16 tested tudor domains, exhibiting Kds greater than 100 μM. |
Molecular Weight | 469.58 |
Formula | C28H31N5O2 |
CAS No. | 2755823-12-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (95.83 mM)
You can also refer to dose conversion for different animals. More
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SETDB1-TTD-IN-1 2755823-12-0 Chromatin/Epigenetic Histone Methyltransferase SETDB1TTDIN1 SETDB1 TTD IN 1 SETDB-1-TTD-IN-1 inhibitor inhibit