Shopping Cart

Remove All
Your shopping cart is currently empty

ROCK inhibitor-2

Name: ROCK inhibitor-2
Brand: TargetMol
SKU: T12746
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12746Cas No. 1127308-52-4

ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 17 nM and 2 nM, respectively.

ROCK inhibitor-2

🥰Excellent

Purity: 99.85%

Catalog No. T12746Cas No. 1127308-52-4

ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 17 nM and 2 nM, respectively.

Pack Size	Price	Availability
1 mg	$60	In Stock
5 mg	$147	In Stock
10 mg	$228	In Stock
25 mg	$455	In Stock
50 mg	$679	In Stock
100 mg	$953	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 17 nM and 2 nM, respectively.
Targets&IC50	ROCK2:2 nM, ROCK1:17 nM

Chemical Properties

Molecular Weight	332.4
Formula	C₂₁H₂₀N₂O₂
Cas No.	1127308-52-4
Smiles	COc1cccc(c1)[C@@H](C)NC(=O)c1ccc(cc1)-c1ccncc1
Relative Density.	1.145 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (752.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0084 mL	15.0421 mL	30.0842 mL	150.4212 mL
5 mM	0.6017 mL	3.0084 mL	6.0168 mL	30.0842 mL
10 mM	0.3008 mL	1.5042 mL	3.0084 mL	15.0421 mL
20 mM	0.1504 mL	0.7521 mL	1.5042 mL	7.5211 mL
50 mM	0.0602 mL	0.3008 mL	0.6017 mL	3.0084 mL
100 mM	0.0301 mL	0.1504 mL	0.3008 mL	1.5042 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc