Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity. |
In vitro | AV-153 demonstrates inhibitory concentration (IC) 50 values of 14.9 mM for Raji cells and 10.3 mM for HL-60 cells[1]. Additionally, administered at concentrations ranging from 1 nM to 10 μM for 3 hours, it lowers the occurrence of DNA single-strand breaks (SSBs) in peripheral blood lymphocytes and HL-60 cells by 13-67%[1]. |
Molecular Weight | 320.297 |
Formula | C14H19NNaO6 |
CAS No. | 27296-05-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AV-153 27296-05-5 AV 153 AV153 inhibitor inhibit