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Icatibant Acetate

Name: Icatibant Acetate
Brand: TargetMol
SKU: T22344
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22344Cas No. 138614-30-9

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.

Icatibant Acetate

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Purity: 99.68%

Catalog No. T22344Cas No. 138614-30-9

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
2 mg	$98	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$528	In Stock	In Stock
50 mg	$753	In Stock	In Stock
100 mg	$987	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$395	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.68%

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COA HPLC MS

Product Introduction

Bioactivity

Description	Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
Targets&IC50	Bradykinin B2:1.07 nM, Bradykinin B2:0.798 nM(ki)
In vitro	Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, leading to a longer half-life than bradykinin which it antagonizes[1].
In vivo	Icatibant treatment exhibits efficacy in bradykinin-mediated angioedema attacks, and rapidly relieves symptom [1].

Chemical Properties

Molecular Weight	1364.57
Formula	C₆₁H₉₃N₁₉O₁₅S
Cas No.	138614-30-9
Smiles	CC(O)=O.[H][C@]12C[C@H](N(C(=O)[C@H]3Cc4ccccc4CN3C(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](N)CCCNC(N)=N)[C@@]1([H])CCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Relative Density.	1.6g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (73.28 mM), Sonication is recommended.

DMSO: 100 mg/mL (73.28 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7328 mL	3.6642 mL	7.3283 mL	36.6416 mL
5 mM	0.1466 mL	0.7328 mL	1.4657 mL	7.3283 mL
10 mM	0.0733 mL	0.3664 mL	0.7328 mL	3.6642 mL
20 mM	0.0366 mL	0.1832 mL	0.3664 mL	1.8321 mL
50 mM	0.0147 mL	0.0733 mL	0.1466 mL	0.7328 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc