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Icatibant Acetate

Name: Icatibant Acetate
Brand: TargetMol
SKU: T22344
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22344Cas No. 138614-30-9

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.

Icatibant Acetate

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Purity: 99.90%

Catalog No. T22344Cas No. 138614-30-9

Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
2 mg	$98	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$313	In Stock	In Stock
25 mg	$528	In Stock	In Stock
50 mg	$753	In Stock	In Stock
100 mg	$987	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$395	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White

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COA MS HPLC

Product Introduction

Bioactivity

Description	Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema.
Targets&IC50	Bradykinin B2:0.798 nM(ki), Bradykinin B2:1.07 nM
In vitro	Icatibant is a decapeptide resistant to the bradykinin-degrading proteases, leading to a longer half-life than bradykinin which it antagonizes[1].
In vivo	Icatibant treatment exhibits efficacy in bradykinin-mediated angioedema attacks, and rapidly relieves symptom [1].

Chemical Properties

Molecular Weight	1364.57
Formula	C₆₁H₉₃N₁₉O₁₅S
Cas No.	138614-30-9
Smiles	CC(O)=O.[H][C@]12C[C@H](N(C(=O)[C@H]3Cc4ccccc4CN3C(=O)[C@H](CO)NC(=O)[C@H](Cc3cccs3)NC(=O)CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](N)CCCNC(N)=N)[C@@]1([H])CCCC2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Relative Density.	1.6g/cm3
Sequence	H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-D-Tic-Oic-Arg-OH.CH3CO2H
Sequence Short	RRPXGXSXXR

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (73.28 mM), Sonication is recommended.

DMSO: 122.5 mg/mL (89.77 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7328 mL	3.6642 mL	7.3283 mL	36.6416 mL
5 mM	0.1466 mL	0.7328 mL	1.4657 mL	7.3283 mL
10 mM	0.0733 mL	0.3664 mL	0.7328 mL	3.6642 mL
20 mM	0.0366 mL	0.1832 mL	0.3664 mL	1.8321 mL
50 mM	0.0147 mL	0.0733 mL	0.1466 mL	0.7328 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc