Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-FGFR3 Antibody (9A8)
😃Good
Catalog No. TMAH-00433
Alias JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH
Anti-FGFR3 Antibody (9A8) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (9A8) can be used in ELISA, IF.
Anti-FGFR3 Antibody (9A8)
Anti-FGFR3 Antibody (9A8)
😃Good
Catalog No. TMAH-00433Alias JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH
Anti-FGFR3 Antibody (9A8) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (9A8) can be used in ELISA, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
Bulk & Custom
Add to Cart
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-FGFR3 Antibody (9A8) is an antibody targeting FGFR3. Anti-FGFR3 Antibody (9A8) can be used in ELISA, IF. |
| Alias | JTK4, HSFGFR3EX, FGFR3, FGFR2 α(IIIb), FGF R3, EC 2.7.10, CEK2, CEK, CD333, ACH |
| Ig Type | Rabbit IgG |
| Clone | 9A8 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of HepG2 Cells with TMAH-00433 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IF |
| Recommended Dose | IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human FGFR3 |
| Antigen Species | Human |
| Gene ID | 2261 |
| Uniprot ID | |
| Biology Area | Cancer, Cardiovascular, Signal transduction, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-FGFR3 Antibody (9A8) | purchase Anti-FGFR3 Antibody (9A8) | Anti-FGFR3 Antibody (9A8) cost | order Anti-FGFR3 Antibody (9A8)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.