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Mtb ATP synthase-IN-1

🥰Excellent
Catalog No. T60877Cas No. 2642394-38-3

Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1] that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.

Mtb ATP synthase-IN-1

Mtb ATP synthase-IN-1

🥰Excellent
Purity: 98.28%
Catalog No. T60877Cas No. 2642394-38-3
Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1] that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
5 mg$82In Stock
10 mg$118In Stock
25 mg$193In Stock
50 mg$286In Stock
100 mg$423In Stock
1 mL x 10 mM (in DMSO)$92In Stock
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Purity:98.28%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1] that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
Targets&IC50
Mtb:0.452-0.499 μg/mL(MIC)
In vivo
In Male CD-1 mouse, Mtb ATP synthase-IN-1 ( 50 mg / kg for PO, 5 mg / kg for IV ; single dosage ; pharmacokinetics Analysis ) can be Exhibited good metabolic stability and acceptable oral bioavailability[1].
Chemical Properties
Molecular Weight323.30
FormulaC17H13N3O4
Cas No.2642394-38-3
SmilesO=C1C(=O)C(NCC2=NC=CC=C2)=C1NC3=CC=C4OCOC4=C3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (309.31 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0931 mL15.4655 mL30.9310 mL154.6551 mL
5 mM0.6186 mL3.0931 mL6.1862 mL30.9310 mL
10 mM0.3093 mL1.5466 mL3.0931 mL15.4655 mL
20 mM0.1547 mL0.7733 mL1.5466 mL7.7328 mL
50 mM0.0619 mL0.3093 mL0.6186 mL3.0931 mL
100 mM0.0309 mL0.1547 mL0.3093 mL1.5466 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ATP Synthase
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