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Mtb ATP synthase-IN-1

Name: Mtb ATP synthase-IN-1
Brand: TargetMol
SKU: T60877
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60877Cas No. 2642394-38-3

Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1] that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.

Mtb ATP synthase-IN-1

🥰Excellent

Purity: 98.28%

Catalog No. T60877Cas No. 2642394-38-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$31	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$116	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$253	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.28%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1] that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
Targets&IC50	Mtb:0.452-0.499 μg/mL(MIC)
In vivo	In Male CD-1 mouse, Mtb ATP synthase-IN-1 ( 50 mg / kg for PO, 5 mg / kg for IV ; single dosage ; pharmacokinetics Analysis ) can be Exhibited good metabolic stability and acceptable oral bioavailability[1].

Chemical Properties

Molecular Weight	323.30
Formula	C₁₇H₁₃N₃O₄
Cas No.	2642394-38-3
Smiles	O=C1C(=O)C(NCC2=NC=CC=C2)=C1NC3=CC=C4OCOC4=C3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (309.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0931 mL	15.4655 mL	30.9310 mL	154.6551 mL
5 mM	0.6186 mL	3.0931 mL	6.1862 mL	30.9310 mL
10 mM	0.3093 mL	1.5466 mL	3.0931 mL	15.4655 mL
20 mM	0.1547 mL	0.7733 mL	1.5466 mL	7.7328 mL
50 mM	0.0619 mL	0.3093 mL	0.6186 mL	3.0931 mL
100 mM	0.0309 mL	0.1547 mL	0.3093 mL	1.5466 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc