Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mtb ATP synthase-IN-1 (compound 6ab) can be used in anti-mycobacterium research. Mtb ATP synthase-IN-1 shoys low cytotoxicity (Vero IC 50 < 64 μg/mL) and acceptable oral bioavailability that has good metabolic stability. Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1].
Pack Size | Availability | Price/USD | Quantity |
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2 mg | 5 days | $ 52.00 |
Description | Mtb ATP synthase-IN-1 (compound 6ab) can be used in anti-mycobacterium research. Mtb ATP synthase-IN-1 shoys low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability that has good metabolic stability. Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) [1]. |
In vivo | Mtb ATP synthase-IN-1 demonstrated good metabolic stability and acceptable oral bioavailability in male CD-1 mice when administered as a single dose of 50 mg/kg orally (PO) and 5 mg/kg intravenously (IV). The pharmacokinetic analysis revealed the following parameters: maximum concentration (C max) was 1333 ng/mL for PO and 1241 ng/mL for IV; time to reach maximum concentration (T max) was 0.83 hours for PO; half-life (T 1/2) was 0.51 hours for PO and 0.33 hours for IV; area under the curve from 0 to last measurable concentration (AUC 0-t) was 2197 ng/mL·h for PO and 1667 ng/mL·h for IV; area under the curve from 0 to infinity (AUC 0-∞) was 2198 ng/mL·h for PO and 1672 ng/mL·h for IV; mean residence time (MRT 0-∞) was 1.36 hours for PO and 0.28 hours for IV; clearance (CL) was 51.4 mL/min/kg; and the bioavailability (F %) was 13.1%. |
Molecular Weight | 323.3 |
Formula | C17H13N3O4 |
CAS No. | 2642394-38-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mtb ATP synthase-IN-1 2642394-38-3 inhibitor inhibit