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Anti-Thioredoxin/TRX Antibody (2S987)
😃Good
Catalog No. TMAY-00735
Alias TXN, TRX1, TRX, TRDX, thioredoxin, RP11-427L11.1, MGC61975, DKFZp686B1993
Anti-Thioredoxin/TRX Antibody (2S987) is a Rabbit antibody targeting Thioredoxin/TRX. Anti-Thioredoxin/TRX Antibody (2S987) can be used in IHC-P.
Anti-Thioredoxin/TRX Antibody (2S987)
Anti-Thioredoxin/TRX Antibody (2S987)
😃Good
Catalog No. TMAY-00735Alias TXN, TRX1, TRX, TRDX, thioredoxin, RP11-427L11.1, MGC61975, DKFZp686B1993
Anti-Thioredoxin/TRX Antibody (2S987) is a Rabbit antibody targeting Thioredoxin/TRX. Anti-Thioredoxin/TRX Antibody (2S987) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: IHC-P Reactivity: Human |
| Alias | TXN, TRX1, TRX, TRDX, thioredoxin, RP11-427L11.1, MGC61975, DKFZp686B1993 |
| Ig Type | Rabbit IgG |
| Clone | 2S987 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human TXN in human colon with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to colonic gland. 2. Immunochemical staining of human TXN in human appendix with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to intestinal gland. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human Thioredoxin / TXN (rh Thioredoxin / TXN; TMPY-02250; P10599; Met1-Val105). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein that belongs to the thioredoxin family. Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin / TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Thioredoxin / TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Thioredoxin / TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Thioredoxin / TXN protein (TMPY-02250) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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