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Guanidine hydrochloride

Guanidine hydrochloride
Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
Catalog No. T0415Cas No. 50-01-1
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Purity:99.68%
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Guanidine hydrochloride

Catalog No. T0415Cas No. 50-01-1

Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
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Product Introduction

Bioactivity
Description
Guanidine hydrochloride (Aminoformamidine Hydrochloride) is a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant.
In vitro
Guanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. [1] Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state. [2] Guanidine HCl is 2.8 times more effective than urea in unfolding ribonuclease but only 1.7 times more effective for lysozyme. △GWaterapp. values of Guanidine HCl are 9.7 Cal/mole for ribonuclease at pH 6.6, 6.1 for lysozyme at pH 2.9, 8.3 for α-chymotrypsin at pH 4.3, and 11.7 for β-lactoglobulin at pH 3.2. [3] Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. [4] 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase. [5]
AliasGuanidine HCl, Aminoformamidine HCl, Aminoformamidine Hydrochloride, Guanidinium chloride
Chemical Properties
Molecular Weight95.53
FormulaCH6ClN3
Cas No.50-01-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (523.4 mM)
H2O: 198.9 mM
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM10.4679 mL52.3396 mL104.6792 mL523.3958 mL
5 mM2.0936 mL10.4679 mL20.9358 mL104.6792 mL
10 mM1.0468 mL5.2340 mL10.4679 mL52.3396 mL
20 mM0.5234 mL2.6170 mL5.2340 mL26.1698 mL
50 mM0.2094 mL1.0468 mL2.0936 mL10.4679 mL
100 mM0.1047 mL0.5234 mL1.0468 mL5.2340 mL

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