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Lufotrelvir

Name: Lufotrelvir
Brand: TargetMol
SKU: T9574
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9574Cas No. 2468015-78-1

Alias PF-07304814

Lufotrelvir (PF-07304814) is a small molecule inhibitor of the SARS CoV-2 3CL protease for the treatment of COVID-19 with broad-spectrum anti-SARS activity for the study of novel coronavirus infections.

Lufotrelvir

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Purity: 99.92%

Catalog No. T9574Alias PF-07304814Cas No. 2468015-78-1

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$48	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$196	In Stock	In Stock
25 mg	$393	In Stock	In Stock
50 mg	$588	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lufotrelvir (PF-07304814) is a small molecule inhibitor of the SARS CoV-2 3CL protease for the treatment of COVID-19 with broad-spectrum anti-SARS activity for the study of novel coronavirus infections.
In vivo	After intravenous administration to rats, dogs, and monkeys, Lufotrelvir exhibits favorable cardiovascular safety and pharmacokinetic parameters[1].
Synonyms	PF-07304814

Chemical Properties

Molecular Weight	552.51
Formula	C₂₄H₃₃N₄O₉P
Cas No.	2468015-78-1
Smiles	O(C)C1=C2C(NC(C(N[C@H](C(N[C@@H](C[C@H]3C(=O)NCC3)C(COP(=O)(O)O)=O)=O)CC(C)C)=O)=C2)=CC=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (180.99 mM), Sonification is recommended.

H2O: 30 mg/mL (54.3 mM), Sonification is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8099 mL	9.0496 mL	18.0992 mL	90.4961 mL
5 mM	0.3620 mL	1.8099 mL	3.6198 mL	18.0992 mL
10 mM	0.1810 mL	0.9050 mL	1.8099 mL	9.0496 mL
20 mM	0.0905 mL	0.4525 mL	0.9050 mL	4.5248 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8099 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.9050 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc