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Concizumab

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Catalog No. T77373Cas No. 1312299-39-0
Alias NN 7415, mAb 2021

Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, blocking its interaction with the FXa active site. Injections of Concizumab increase thrombin in blood, thereby preventing and treating hemophilia.

Concizumab

Concizumab

🥰Excellent
Catalog No. T77373Alias NN 7415, mAb 2021Cas No. 1312299-39-0
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, blocking its interaction with the FXa active site. Injections of Concizumab increase thrombin in blood, thereby preventing and treating hemophilia.
Pack SizePriceAvailabilityQuantity
1 mg$228In Stock
5 mg$589In Stock
10 mg$967In Stock
25 mg$1,430In Stock
50 mg$1,930In Stock
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Concentration:6.34 mg/mL
Purity:> 95%
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COA SDS-PAGE SEC-HPLC Instruction Manual of Inhibitory Antibody

Product Introduction

Bioactivity
Description
Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, blocking its interaction with the FXa active site. Injections of Concizumab increase thrombin in blood, thereby preventing and treating hemophilia.
In vitro
In a concentration-dependent manner, Concizumab increases the peak value of thrombin [1].
In vivo
In cynomolgus monkeys, Concizumab (i.v./s.c.) blocked the interaction between TFPI and FXa active site [2].
SynonymsNN 7415, mAb 2021
Chemical Properties
Molecular Weight145.76 kDa
Cas No.1312299-39-0
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

NN-7415NN7415Concizumab
Related Tags: buy Concizumab | purchase Concizumab | Concizumab cost | order Concizumab | Concizumab in vivo | Concizumab in vitro | Concizumab molecular weight
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