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Concizumab

Catalog No. T77373 CAS 1312299-39-0

Synonyms: mAb 2021, NN 7415

Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, thereby blocking the interaction of this domain with the FXa active site. Injections of Concizumab increase thrombin in the blood and can be used to prevent and treat hemophilia.

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Concizumab

Concizumab, CAS 1312299-39-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 289.00
5 mg	In stock	$ 755.00
10 mg	In stock	$ 1,190.00
25 mg	In stock	$ 1,780.00
50 mg	In stock	$ 2,430.00
100 mg	In stock	$ 3,270.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Concizumab is an anti-TFPI monoclonal antibody (IgG4 type) that selectively binds to the Kunitz protease inhibitor (KPI) 2 domain of TFPI, thereby blocking the interaction of this domain with the FXa active site. Injections of Concizumab increase thrombin in the blood and can be used to prevent and treat hemophilia.
In vitro	In a concentration-dependent manner, Concizumab increases the peak value of thrombin [1].
In vivo	In cynomolgus monkeys, Concizumab (i.v./s.c.) blocked the interaction between TFPI and FXa active site [2].

Synonyms	mAb 2021, NN 7415
Molecular Weight	N/A
CAS No.	1312299-39-0

Storage

store at low temperature

store at -80°C

References and Literature

1. Kjalke M, et al. Thrombin generation potential in the presence of concizumab and rFVIIa, APCC, rFVIII, or rFIX: In vitro and ex vivo analyses. J Thromb Haemost. 2021 Jul;19(7):1687-1696. 2. Agersø H, et al. Pharmacokinetics of an anti-TFPI monoclonal antibody (concizumab) blocking the TFPI interaction with the active site of FXa in Cynomolgus monkeys after iv and sc administration. Eur J Pharm Sci. 2014 Jun 2;56:65-9.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Concizumab 1312299-39-0 Others mAb 2021 NN 7415 NN-7415 NN7415 inhibitor inhibit

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