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Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

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Catalog No. T40094Cas No. 2435572-48-6
Alias Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2, E3LigaseLigand-LinkerConjugates23, Cereblon Ligand-Linker Conjugates 12

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
Other Forms of Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2:
Thalidomide-O-amido-PEG1-(C1-​PEG)2-C2-NH2T17917
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Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

😃Good
Catalog No. T40094Alias Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2, E3LigaseLigand-LinkerConjugates23, Cereblon Ligand-Linker Conjugates 12Cas No. 2435572-48-6
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.
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Product Introduction

Bioactivity
Description
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.
In vitro
PROTACs consist of two distinct ligands linked together: one targets an E3 ubiquitin ligase, and the other binds to a target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [2].
SynonymsThalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2, E3LigaseLigand-LinkerConjugates23, Cereblon Ligand-Linker Conjugates 12
Chemical Properties
Molecular Weight534.566
FormulaC25H34N4O9
Cas No.2435572-48-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Cereblon Ligand-Linker Conjugates 12Thalidomide-O-amido-PEG-1-(C1-PEG)2-C2-NH2ThalidomideOamidoPEG1(C1PEG)2C2NH2Thalidomide O amido PEG1 (C1 PEG)2 C2 NH2
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