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TAK-615

Name: TAK-615
Brand: TargetMol
SKU: T9699
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9699Cas No. 1664335-55-0

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

TAK-615

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Purity: 99.73%

Catalog No. T9699Cas No. 1664335-55-0

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$69	-	In Stock
5 mg	$172	-	In Stock
10 mg	$273	-	In Stock
25 mg	$451	-	In Stock
50 mg	$636	-	In Stock
100 mg	$858	-	In Stock
500 mg	$1,710	-	In Stock
1 mL x 10 mM (in DMSO)	$190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
Targets&IC50	LPA1 Receptor:1.7-14.5 nM (Kd)
In vitro	TAK-615 specifically binds to membranes expressing the human LPA1 receptor with high affinity (Kd = 1.7 ± 0.5 nM) and low affinity (Kd = 14.5 ± 12.1 nM). TAK-615 partially inhibits the LPA response (~40% at 10 μM, IC50 = 23 ± 13 nM in β-arrestin assay; 60% at 10 μM, IC50 = 91 ± 30 nM in calcium mobilization assay). [1]

Chemical Properties

Molecular Weight	419.44
Formula	C₂₅H₂₂FNO₄
Cas No.	1664335-55-0
Smiles	OC(=O)c1ccc(CN(CC2CC2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1
Relative Density.	1.302 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (286.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3841 mL	11.9207 mL	23.8413 mL	119.2066 mL
5 mM	0.4768 mL	2.3841 mL	4.7683 mL	23.8413 mL
10 mM	0.2384 mL	1.1921 mL	2.3841 mL	11.9207 mL
20 mM	0.1192 mL	0.5960 mL	1.1921 mL	5.9603 mL
50 mM	0.0477 mL	0.2384 mL	0.4768 mL	2.3841 mL
100 mM	0.0238 mL	0.1192 mL	0.2384 mL	1.1921 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc