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Anti-Phospho-Separase (Ser1073) Polyclonal Antibody
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Catalog No. TMAB-11270
Anti-Phospho-Separase (Ser1073) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Separase (Ser1073). Anti-Phospho-Separase (Ser1073) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-Separase (Ser1073) Polyclonal Antibody
Anti-Phospho-Separase (Ser1073) Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-11270
Anti-Phospho-Separase (Ser1073) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Separase (Ser1073). Anti-Phospho-Separase (Ser1073) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Phospho-Separase (Ser1073) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Separase (Ser1073). Anti-Phospho-Separase (Ser1073) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (Human cervical cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (p-Separase (Ser1073)) Polyclonal Antibody, Unconjugated (TMAB-11270) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasmic and Nuclear |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human ESPL1 around the phosphorylation site of Ser1073 |
| Antigen Species | Human |
| Gene Name | ESPL1 |
| Gene ID | |
| Protein Name | Separin |
| Uniprot ID | |
| Function | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. |
| Molecular Weight | Theoretical: 198 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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