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Anti-GPVI Polyclonal Antibody
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Catalog No. TMAB-00804
Alias MGC138168, GPVI, Gp6, Glycoprotein 6
Anti-GPVI Polyclonal Antibody is a Rabbit antibody targeting GPVI. Anti-GPVI Polyclonal Antibody can be used in WB.
Anti-GPVI Polyclonal Antibody
Anti-GPVI Polyclonal Antibody
😃Good
Catalog No. TMAB-00804Alias MGC138168, GPVI, Gp6, Glycoprotein 6
Anti-GPVI Polyclonal Antibody is a Rabbit antibody targeting GPVI. Anti-GPVI Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-GPVI Polyclonal Antibody is a Rabbit antibody targeting GPVI. Anti-GPVI Polyclonal Antibody can be used in WB. |
| Synonyms | MGC138168, GPVI, Gp6, Glycoprotein 6 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Pig,Cow,Horse) |
| Verified Activity | Sample: Lane 1: Mouse Spleen Lysates Lane 2: Mouse Testis Lysates Lane 3: Rat Spleen Lysates Lane 4: Rat Testis Lysates Lane 5: Human K562 cell Lysates Lane 6: Human U-2 OS cell Lysates Primary: Anti-Glycoprotein VI (TMAB-00804) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kDa Observed band size: 65 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1: Cell membrane; Single-pass membrane protein. Isoform 2: Cell membrane; Single-pass membrane protein. |
| Tissue Specificity | Megakaryocytes and platelets. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]. |
| Immunogen | KLH conjugated synthetic peptide: human GPVI/Glycoprotein VI |
| Antigen Species | Human |
| Gene Name | GP6 |
| Gene ID | |
| Protein Name | Platelet glycoprotein VI |
| Uniprot ID | |
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. |
| Molecular Weight | Theoretical: 35 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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