Anti-HIF-1 alpha Polyclonal Antibody 3

Name: Anti-HIF-1 alpha Polyclonal Antibody 3
Brand: TargetMol
SKU: TMAB-00857
Rating: 4.5 (1 reviews)

(Synonyms: PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78) Copy Product Info

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Synonyms: PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78

Catalog No. TMAB-00857 Copy Product Info

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Anti-HIF-1 alpha Polyclonal Antibody 3 is a Rabbit antibody targeting HIF-1 alpha. Anti-HIF-1 alpha Polyclonal Antibody 3 can be used in FCM, WB.

Anti-HIF-1 alpha Polyclonal Antibody 3

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$374	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-HIF-1 alpha Polyclonal Antibody 3 is a Rabbit antibody targeting HIF-1 alpha. Anti-HIF-1 alpha Polyclonal Antibody 3 can be used in FCM, WB.
Synonyms	PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78
Ig Type	IgG
Reactivity	Human (predicted:Mouse,Rat,Chicken)

Application	FCM WB
Recommended Dose	FCM=1 μg/Test; WB=1:1000-5000
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm. Nucleus.
Tissue Specificity	Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumo
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4.
Concentration	1 mg/mL
Research Background	Hypoxia inducible factor alpha not only plays a particularly important role in maintaining normal physiological functions of the body under hypoxic conditions, but also plays a crucial role in pathological processes such as tumor growth and neuronal apoptosis HIF1 alpha can regulate the expression levels of many downstream genes Mammalian cells exhibit HIF under low oxygen pressure conditions. HIF is a transcription factor that stabilizes cellular hypoxia.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human HIF-1 Alpha
Antigen Species	Human
Gene Name	HIF1A
Gene ID	3091
Protein Name	Hypoxia-inducible factor 1-alpha
Uniprot ID	Q16665
Biology Area	HIF,Hydroxylases,HIF,Jumonji containing proteins,Methylation
Function	Functions as a master transcriptional regulator of theadaptive response to hypoxia. Under hypoxic conditions activatesthe transcription of over 40 genes, including, erythropoietin,glucose transporters, glycolytic enzymes, vascular endothelialgrowth factor, and other genes whose protein products increaseoxygen delivery or facilitate metabolic adaptation to hypoxia.Plays an essential role in embryonic vascularization, tumorangiogenesis and pathophysiology of ischemic disease. Binds to coreDNA sequence 5'-[AG]CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment oftranscriptional coactivators such as CREBPB and EP300. Activity isenhanced by interaction with both, NCOA1 or NCOA2. Interaction withredox regulatory protein APEX seems to activate CTAD andpotentiates activation by NCOA1 and CREBBP.