CD3 zeta/CD247 Protein, Human, Recombinant

CD3 zeta/CD247 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.18 kDa and the accession number is P20963-1.

Pack Size	Availability	Price/USD	Quantity
100 μg	5 days	$ 700.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 700.00

Description

CD3 zeta/CD247 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.18 kDa and the accession number is P20963-1.

Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P20963-1
Synonyms	CD3Q, IMD25, CD3H, T3Z, CD3-ζ, CD3 ζ/CD247, TCRZ, CD3Z, CD3-ZETA, CD247 molecule
Construction	Human CD247 (P20963-1) (Arg52-Arg164)
Protein Purity	> 90 % as determined by SDS-PAGE.
Molecular Weight	13.18 kDa (predicted)

Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 150 mM NaCl, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.