CD3 zeta/CD247 Protein, Human, Recombinant

Name: CD3 zeta/CD247 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-06481
Rating: 4.5 (1 reviews)

(Synonyms: TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule) Copy Product Info

Synonyms: TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule

Catalog No. TMPY-06481 Copy Product Info

CD3 zeta/CD247 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.18 kDa and the accession number is P20963-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$79	7-10 days	7-10 days
10 µg	$129	7-10 days	7-10 days
20 µg	$208	7-10 days	7-10 days
50 µg	$419	7-10 days	7-10 days
100 µg	$812	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	CD3 zeta/CD247 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.18 kDa and the accession number is P20963-1.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P20963-1
Construction	A DNA sequence encoding the human CD247 (P20963-1) (Arg52-Arg164) was expressed. Predicted N terminal: Gly
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 150 mM NaCl, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule
Research Background	CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

Chemical Properties

Molecular Weight

13.18 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.