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THAL-SNS-032

Name: THAL-SNS-032
Brand: TargetMol
SKU: T17069
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17069Cas No. 2139287-33-3

THAL-SNS-032 is a PROTAC designed to selectively degrade CDK9.

THAL-SNS-032

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Purity: 99.68%

Catalog No. T17069Cas No. 2139287-33-3

THAL-SNS-032 is a PROTAC designed to selectively degrade CDK9.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$288	In Stock	In Stock
10 mg	$432	In Stock	In Stock
25 mg	$691	In Stock	In Stock
50 mg	$983	In Stock	In Stock
100 mg	$1,330	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$433	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

THAL-SNS-032 AI Summary

THAL-SNS-032 demonstrates potent Protac activity at CRBN/CDK9 in human MOLT4 cells, inducing CDK9 protein degradation within 6 hours as confirmed by Western blot analysis. It exhibits a DC50 value of less than 250.0 nM and an Emax value exceeding 95.0%, indicating its strong impact on CDK9 degradation. Additionally, THAL-SNS-032 shows significant antiproliferative activity against MOLT4 cells with an IC50 of 50.0 nM over a 72-hour incubation period. The compound also possesses high thermodynamic solubility in phosphate buffer at pH 7, measured at 52480.0 nM. In human 22Rv1 cells, it induces Cyclin T1 degradation with 40.18% activity at 3 µM over 24 hours and demonstrates antiproliferative activity with an IC50 of 49.0 nM after 5 days. The compound’s effects on cell viability and growth exhibit cell-type specificity, impacting growth rates differently across HEK293T, U2OS, and human fibroblast cells. Furthermore, THAL-SNS-032 affects the thermal stability of various protein domains, either enhancing or diminishing melting temperatures in a domain-specific manner..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

THAL-SNS-032 is a PROTAC designed to selectively degrade CDK9.

Chemical Properties

Molecular Weight	869.02
Formula	C₄₀H₅₂N₈O₁₀S₂
Cas No.	2139287-33-3
Smiles	O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCOCCNC(CN4CCC(C(NC=5SC(SCC=6OC(C(C)(C)C)=CN6)=CN5)=O)CC4)=O
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (172.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1507 mL	5.7536 mL	11.5072 mL	57.5361 mL
5 mM	0.2301 mL	1.1507 mL	2.3014 mL	11.5072 mL
10 mM	0.1151 mL	0.5754 mL	1.1507 mL	5.7536 mL
20 mM	0.0575 mL	0.2877 mL	0.5754 mL	2.8768 mL
50 mM	0.0230 mL	0.1151 mL	0.2301 mL	1.1507 mL
100 mM	0.0115 mL	0.0575 mL	0.1151 mL	0.5754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc