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Galloflavin

Name: Galloflavin
Brand: TargetMol
SKU: T22336
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22336Cas No. 568-80-9

Galloflavin is a lactate dehydrogenase inhibitor that inhibits the activity of lactate dehydrogenase. Galloflavin inhibits both human LDH isoforms (type A and type B) by preferentially binding to the free enzyme without competing with substrates or cofactors, with Ki values calculated by pyruvate of 5.46 μM (LDH-A) and 15.06 μM (LDH-B).

Galloflavin

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Purity: 97.47%

Catalog No. T22336Cas No. 568-80-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$36	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$682	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.47%

Appearance:Solid

Color:Yellow

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COA HNMR HPLC

Product Introduction

Galloflavin AI Summary

Galloflavin exhibits inhibitory activity towards LDHA in the human liver and LDHB in the human heart. This compound has a Ki value of 5460.0 nM for LDHA and 15060.0 nM for LDHB using pyruvate as a substrate in a fluorescence assay with a 3-minute incubation period..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Galloflavin is a lactate dehydrogenase inhibitor that inhibits the activity of lactate dehydrogenase. Galloflavin inhibits both human LDH isoforms (type A and type B) by preferentially binding to the free enzyme without competing with substrates or cofactors, with Ki values calculated by pyruvate of 5.46 μM (LDH-A) and 15.06 μM (LDH-B).
Targets&IC50	LDHB:15.06 μM, LDHA:5.46 μM
In vitro	METHODS: Galloflavin (5, 15 μM) was used to treat SW480 cells, and cell viability was measured and cell migration and wound healing tests were performed to study its effects on the cells in an inflammatory environment. RESULTS Galloflavin can inhibit the upregulation of cell viability of SW480 cells in an inflammatory microenvironment, and also inhibit their migration and invasion in an inflammatory environment. Wound healing showed inhibition of the migration ability of the cells. [1]
In vivo	METHODS: Galloflavin (5, 15 mg/kg, 15 days) was used to treat tumor xenograft-bearing mice. The tumors were removed and the tumor volume was measured to study its effect on tumors in mice. Western Blot experiments were performed to detect the expression levels of related proteins in mice. RESULTS Galloflavin can significantly inhibit tumor growth, and the inhibition of tumor growth and tumor volume is time-dependent. Protein detection found that Galloflavin can inhibit the expression of NLRP3, c-Myc and P21. [1]

Chemical Properties

Molecular Weight	278.17
Formula	C₁₂H₆O₈
Cas No.	568-80-9
Smiles	Oc1cc2c(c(O)c1O)c1oc(=O)c(O)cc1oc2=O
Relative Density.	2.10 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (197.72 mM), Sonication is recommended.

DMF: 1.11 mg/mL (3.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.8 mg/mL (10.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5949 mL	17.9746 mL	35.9492 mL	179.7462 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.7190 mL	3.5949 mL	7.1898 mL	35.9492 mL
10 mM	0.3595 mL	1.7975 mL	3.5949 mL	17.9746 mL
20 mM	0.1797 mL	0.8987 mL	1.7975 mL	8.9873 mL
50 mM	0.0719 mL	0.3595 mL	0.7190 mL	3.5949 mL
100 mM	0.0359 mL	0.1797 mL	0.3595 mL	1.7975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc