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Edoxaban Tosylate Monohydrate

Name: Edoxaban Tosylate Monohydrate
Brand: TargetMol
SKU: T2368
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2368Cas No. 1229194-11-9

Alias edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrate

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Edoxaban Tosylate Monohydrate

🥰Excellent

Purity: 99.91%

Catalog No. T2368Alias edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrateCas No. 1229194-11-9

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$61	In Stock
25 mg	$88	In Stock
50 mg	$116	In Stock
100 mg	$162	In Stock
500 mg	$397	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Purity:99.91%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Targets&IC50	FXa:0.561 nM(Ki)
In vitro	In thrombosis models involving rats and rabbits, Edoxaban demonstrates a dose-dependent inhibition of thrombus formation. Edoxaban (p.o.) elicits effective anti-Xa activity and achieves high plasma drug concentrations in both rats and monkeys.
In vivo	Edoxaban (0.256 and 0.508 μM) doubles the prothrombin time in human plasma and partially activates the thromboplastin time.
Synonyms	edoxaban tosylate hydrate, DU-176b tosylate Monohydrate, DU-176b monohydrate

Chemical Properties

Molecular Weight	738.27
Formula	C₃₁H₄₀ClN₇O₈S₂
Cas No.	1229194-11-9
Smiles	O.Cc1ccc(cc1)S(O)(=O)=O.CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(=O)Nc2ccc(Cl)cn2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (125.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.47 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3545 mL	6.7726 mL	13.5452 mL	67.7259 mL
5 mM	0.2709 mL	1.3545 mL	2.7090 mL	13.5452 mL
10 mM	0.1355 mL	0.6773 mL	1.3545 mL	6.7726 mL
20 mM	0.0677 mL	0.3386 mL	0.6773 mL	3.3863 mL
50 mM	0.0271 mL	0.1355 mL	0.2709 mL	1.3545 mL
100 mM	0.0135 mL	0.0677 mL	0.1355 mL	0.6773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc