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Transdermal Peptide TD-1 HCl
🥰Excellent
Catalog No. T37766L
Alias Transdermal Peptide TD-1 HCl（918629-48-8 Free base), TD1 (peptide) HCl, TD 1 (peptide) HCl
Transdermal Peptide TD-1 HCl is a novel peptide for enhanced transdermal drug delivery that facilitates the penetration of the skin barrier by several drugs and large hydrophilic proteins, such as insulin and human growth hormoneb.
Transdermal Peptide TD-1 HCl
🥰Excellent
Purity: 97.03%
Catalog No. T37766LAlias Transdermal Peptide TD-1 HCl（918629-48-8 Free base), TD1 (peptide) HCl, TD 1 (peptide) HCl
Transdermal Peptide TD-1 HCl is a novel peptide for enhanced transdermal drug delivery that facilitates the penetration of the skin barrier by several drugs and large hydrophilic proteins, such as insulin and human growth hormoneb.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | - | In Stock | |
| 5 mg | $70 | - | In Stock | |
| 10 mg | $107 | - | In Stock | |
| 25 mg | $180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.03%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Transdermal Peptide TD-1 HCl is a novel peptide for enhanced transdermal drug delivery that facilitates the penetration of the skin barrier by several drugs and large hydrophilic proteins, such as insulin and human growth hormoneb. |
| In vitro | In vitro, 0.5 mg/mL Transdermal Peptide TD-1 HCl markedly enhanced the transdermal penetration of curcumin liposomes (Cur-Lips) in mouse skin models (Qₙ = 2.20 μg/cm²/h), and maintained strong anti-melanoma activity even in the presence of 150 mM NaCl and serum. Transdermal Peptide TD-1 HCl combined with Cur-Lips significantly inhibited B16F10 melanoma cell proliferation (P < 0.001), while Transdermal Peptide TD-1 HCl alone showed no cytotoxicity at low concentrations[1]. |
| In vivo | In vivo, topical application of Transdermal Peptide TD-1 HCl (0.5 mg/mL) with Cur-Lips gel twice daily for 12 days significantly reduced tumor volume and weight in B16F10 melanoma-bearing mice (P < 0.001), induced tumor cell apoptosis, and downregulated serum VEGF levels[1]. |
| Synonyms | Transdermal Peptide TD-1 HCl（918629-48-8 Free base), TD1 (peptide) HCl, TD 1 (peptide) HCl |
| Molecular Weight | 1099.63 |
| Formula | C40H67ClN14O16S2 |
| Smiles | C[C@H](N)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CS)C(NCC(O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)=O)=O)=O.Cl |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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