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ZT-12-037-01

🥰Excellent
Catalog No. T5597Cas No. 2328073-61-4

Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).

ZT-12-037-01

ZT-12-037-01

🥰Excellent
Purity: 99.56%
Catalog No. T5597Cas No. 2328073-61-4
Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$68In StockIn Stock
10 mg$117In StockIn Stock
25 mg$236In StockIn Stock
50 mg$396In StockIn Stock
100 mg$619In StockIn Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.56%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
Targets&IC50
STK19 (D89N):27.94 nM , STK19 (WT):23.96 nM
In vitro
ZT-12-037-01 significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation.
In vivo
ZT-12-037-01 as a specific STK19-targeted inhibitor and it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vivo.
Animal Research
ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3.
Chemical Properties
Molecular Weight385.5
FormulaC21H31N5O2
Cas No.2328073-61-4
SmilesCOc1cc2nc(NC3CC3)nc(NC3CCN(CC3)C(C)C)c2cc1OC
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 41 mg/mL (106.36 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5940 mL12.9702 mL25.9403 mL129.7017 mL
5 mM0.5188 mL2.5940 mL5.1881 mL25.9403 mL
10 mM0.2594 mL1.2970 mL2.5940 mL12.9702 mL
20 mM0.1297 mL0.6485 mL1.2970 mL6.4851 mL
50 mM0.0519 mL0.2594 mL0.5188 mL2.5940 mL
100 mM0.0259 mL0.1297 mL0.2594 mL1.2970 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

ZT-12-037-01ZT1203701ZT 12 037 01STK19SerineProteaseSerine ProteaseRasInhibitorinhibit
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