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ZT-12-037-01

Name: ZT-12-037-01
Brand: TargetMol
SKU: T5597
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5597Cas No. 2328073-61-4

Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).

ZT-12-037-01

🥰Excellent

Purity: 99.56%

Catalog No. T5597Cas No. 2328073-61-4

Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$236	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$619	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
Targets&IC50	STK19 (WT):23.96 nM , STK19 (D89N):27.94 nM
In vitro	ZT-12-037-01 significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation.
In vivo	ZT-12-037-01 as a specific STK19-targeted inhibitor and it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vivo.
Animal Research	ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3.

Chemical Properties

Molecular Weight	385.5
Formula	C₂₁H₃₁N₅O₂
Cas No.	2328073-61-4
Smiles	COc1cc2nc(NC3CC3)nc(NC3CCN(CC3)C(C)C)c2cc1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41 mg/mL (106.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5940 mL	12.9702 mL	25.9403 mL	129.7017 mL
5 mM	0.5188 mL	2.5940 mL	5.1881 mL	25.9403 mL
10 mM	0.2594 mL	1.2970 mL	2.5940 mL	12.9702 mL
20 mM	0.1297 mL	0.6485 mL	1.2970 mL	6.4851 mL
50 mM	0.0519 mL	0.2594 mL	0.5188 mL	2.5940 mL
100 mM	0.0259 mL	0.1297 mL	0.2594 mL	1.2970 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc