Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NUC-7738, a 5′-aryloxy phosphoramidate prodrug of 3′-deoxyadenosine (3′-dA), exhibits potent cytotoxic activity against various hematological cancer cell lines and is utilized in cancer research [1].
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Description | NUC-7738, a 5′-aryloxy phosphoramidate prodrug of 3′-deoxyadenosine (3′-dA), exhibits potent cytotoxic activity against various hematological cancer cell lines and is utilized in cancer research [1]. |
In vitro | NUC-7738 (compound 7a; 0-198 μM; 72 h; various cell lines including CCRF-CEM, HL-60, KG-1, MOLT-4, K562, MV4-11, THP-1, HEL92, NCI-H929, RPMI-8226, Jurkat, Z138, RL, HS445, HepG2, MCF-7, Bx-PC-3, HT29, MIA PaCa-2, and SW620) exhibits anticancer activity and cytotoxicity within the leukocyte lineage, with LC50 values of <30 μM [1]. NUC-7738 demonstrates good stability in human hepatocytes with a half-life (t1/2) of 48.1 minutes [1]. Compared to its parent nucleoside, NUC-7738 shows greater stability in human plasma, maintaining consistent plasma concentrations for up to 4 hours [1]. |
Molecular Weight | 568.52 |
Formula | C26H29N6O7P |
CAS No. | 2348493-39-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NUC-7738 2348493-39-8 Others inhibitor inhibit