Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CNBCA, a selective and potent competitive inhibitor of the SHP2 enzyme, exhibits an IC50 value of 0.87 μM. It binds to the full-length SHP2, effectively inhibiting its enzyme activity, as well as impeding pAkt and pERK1/2. Furthermore, CNBCA suppresses the proliferation of BT474 and MDA-MB468 cells, indicating potential utility in breast cancer research [1].
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Description | CNBCA, a selective and potent competitive inhibitor of the SHP2 enzyme, exhibits an IC50 value of 0.87 μM. It binds to the full-length SHP2, effectively inhibiting its enzyme activity, as well as impeding pAkt and pERK1/2. Furthermore, CNBCA suppresses the proliferation of BT474 and MDA-MB468 cells, indicating potential utility in breast cancer research [1]. |
In vitro | CNBCA (0.25, 0.50, 1, 2 μM, 48 h) inhibits SHP2-mediated activation of Akt and ERK1/2 in BT474 and MDA-MB-468 cells, with an IC50 of approximately 1.0 μM [1]. Furthermore, CNBCA (500 nM, 24-72 h) suppresses the growth of BT474 and MDA-MB-468 cells [1]. |
Molecular Weight | 426.55 |
Formula | C26H34O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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