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Palmatine chloride

Name: Palmatine chloride
Brand: TargetMol
SKU: T2718
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2718Cas No. 10605-02-4

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.

Palmatine chloride

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Purity: 99.47%

Catalog No. T2718Cas No. 10605-02-4

Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$35	-	In Stock
1 g	$54	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.47%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Palmatine chloride AI Summary

Palmatine chloride exhibits a diverse range of bioactivities across various biological targets and systems. It shows potent antimalarial activity in vitro against Plasmodium falciparum strains D6 (IC50 = 0.281 µg/mL) and W2 (IC50 = 0.163 µg/mL), as well as in vivo efficacy in Plasmodium berghei-infected mice, demonstrating a significant improvement in mean survival time at 40 mg/kg. Additionally, it inhibits human CYP3A4 enzyme with an IC50 value of 900 nM and various GTPase activities including Rac1b, Cdc42, and Rac1. Palmatine chloride also displays inhibitory effects on human Jumonji Domain Containing 2E (JMJD2E), Tau Fibril Formation, ERK Signaling Pathway, and several other enzymes and signaling pathways. It binds to calf thymus DNA, indicating potential DNA interaction bioactivity, with a binding constant (Kapp) of 8.72 × 10^3/M. Furthermore, the compound demonstrates estrogenic activity in human MVLN cells and exhibits certain antifungal properties against Zymoseptoria tritici on wheat plants. In terms of antiviral and antibacterial activities, Palmatine chloride shows some inhibitory action against SARS-CoV-2 in Caco-2 cells, albeit with varying inhibition percentages, and exhibits antibacterial activity against Staphylococcus aureus with an MIC of 250.0 µg/mL. Additionally, it significantly inhibits sodium fluorescein uptake in OATP1B1- and OATP1B3-transfected CHO cells. Despite its various bioactivities, Palmatine chloride shows low cytotoxicity against human hepatocellular carcinoma cell line (Huh7) and other tested human cell lines, with a CC50 value greater than 100,000 nM. It has also shown promising antitumor effects in mouse xenograft models, reducing tumor growth and tumor weight in human H22 cell xenografted ICR mice. Overall, Palmatine chloride presents a potential for the development of treatments for multiple conditions, including malaria, cancer, and possibly some bacterial and viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
Targets&IC50	WNV NS2B-NS3:96 μM, IDO1:3 μM (HEK 293-hIDO-1), IDO1:157 μM (rhIDO-1)

Chemical Properties

Molecular Weight	387.86
Formula	C₂₁H₂₂ClNO₄
Cas No.	10605-02-4
Smiles	[Cl-].COc1cc2CC[n+]3cc4c(OC)c(OC)ccc4cc3-c2cc1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10.00 mg/mL (25.78 mM), Sonication is recommended.

Ethanol: 12.00 mg/mL (30.94 mM), Sonication is recommended.

H2O: 5.00 mg/mL (12.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (2.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5782 mL	12.8912 mL	25.7825 mL	128.9125 mL
5 mM	0.5156 mL	2.5782 mL	5.1565 mL	25.7825 mL
10 mM	0.2578 mL	1.2891 mL	2.5782 mL	12.8912 mL

DMSO/Ethanol

	1mg	5mg	10mg	50mg
20 mM	0.1289 mL	0.6446 mL	1.2891 mL	6.4456 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc