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Losartan potassium

Name: Losartan potassium
Brand: TargetMol
SKU: T0215
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0215Cas No. 124750-99-8

Alias MK 954, DuP-753 potassium, DuP 753

Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.

Losartan potassium

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Purity: 99.98%

Catalog No. T0215Alias MK 954, DuP-753 potassium, DuP 753Cas No. 124750-99-8

Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$33	In Stock	In Stock
1 g	$45	In Stock	In Stock
5 g	$107	-	In Stock
10 g	$156	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Losartan potassium (DuP-753 potassium), an Angiotensin II Receptor Blocker, selectively and competitively inhibits the binding of angiotensin II to the angiotensin I (AT1) receptor.
Targets&IC50	AT1 receptor:20 nM
In vitro	Losartan competes with the binding of angiotensin II to AT1 receptors, with an IC50 of 20 nM[1]. At 40 μM, losartan affects ISC and prevents the effect of ANGII on ISC[2]. It significantly reduces Ang II-mediated cell proliferation in endometrial cancer cells, and in combination with anti-miR-155, it exhibits a significantly greater antiproliferative effect compared to each drug alone[3].
Cell Research	An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival.
Synonyms	MK 954, DuP-753 potassium, DuP 753

Chemical Properties

Molecular Weight	461.01
Formula	C₂₂H₂₂ClKN₆O
Cas No.	124750-99-8
Smiles	[K+].CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[n-]1
Relative Density.	0.986?g/mL?at 25?°C(lit.)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 46.1 mg/mL (100 mM), Sonication is recommended.

DMSO: 250 mg/mL (542.29 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1692 mL	10.8458 mL	21.6915 mL	108.4575 mL
5 mM	0.4338 mL	2.1692 mL	4.3383 mL	21.6915 mL
10 mM	0.2169 mL	1.0846 mL	2.1692 mL	10.8458 mL
20 mM	0.1085 mL	0.5423 mL	1.0846 mL	5.4229 mL
50 mM	0.0434 mL	0.2169 mL	0.4338 mL	2.1692 mL
100 mM	0.0217 mL	0.1085 mL	0.2169 mL	1.0846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc