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Mangiferin

Name: Mangiferin
Brand: TargetMol
SKU: T3012
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3012Cas No. 4773-96-0

Alias Hedysarid, Chinomin, Alpizarin

Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.

Mangiferin

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Purity: 99.86%

Catalog No. T3012Alias Hedysarid, Chinomin, AlpizarinCas No. 4773-96-0

Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$38	In Stock	In Stock
50 mg	$46	In Stock	In Stock
100 mg	$56	In Stock	In Stock
500 mg	$133	In Stock	In Stock
1 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Mangiferin AI Summary

Mangiferin is a multifunctional molecule exhibiting significant biological activities across various assays. It inhibits Clostridium perfringens neuraminidase with an IC50 of 16200.0 nM and aldose reductase in rat lens homogenate with an IC50 of 3200.0 nM. Additionally, it demonstrates antioxidant properties through a DPPH radical scavenging assay (IC50 of 35020.0 nM) and shows antiplasmodial activity against Plasmodium falciparum 3D7 with an IC50 of 23800.0 nM. The compound also inhibits Saccharomyces cerevisiae alpha-glucosidase (IC50 of 296000.0 nM) and alpha-glucosidase from an unspecified source, revealing a bioactivity profile against enzymes crucial to microbial and metabolic processes. The compound exerts anti-inflammatory effects by inhibiting LPS-induced NO production in mouse BV2 cells, showing over 80% inhibition at 50 μM and a corresponding IC50 of 38500.0 nM. It also demonstrates antiviral activities, including inhibition of Influenza A virus neuraminidase (18.4%) and Coxsackievirus B3 3C protease (21.4%) at 100 μM, and shows moderate inhibition of SARS-CoV-2 3CL-Pro protease (17.49% at 20µM). In terms of antimicrobial efficacy, it inhibits Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase (IC50 of 149000.0 nM) and exhibits antiplatelet aggregatory activity in human blood. Moreover, it possesses antitumor properties, significantly inhibiting the growth of xenografted human U2OS cells in mice and improving survival durations. Pharmacokinetic studies in Wistar rats suggest that Mangiferin has reasonable solubility and bioavailability in different physiological conditions, as well as varied metabolic and excretion profiles depending on the presence of diabetes or other physiological states. Overall, Mangiferin reveals a broad spectrum of bioactivities, including enzymatic inhibition, antioxidant potential, anti-inflammatory effects, antiviral, antimicrobial, and potent antitumor properties, along with favorable pharmacokinetic characteristics, positioning it as a promising candidate for further drug development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.
Synonyms	Hedysarid, Chinomin, Alpizarin

Chemical Properties

Molecular Weight	422.34
Formula	C₁₉H₁₈O₁₁
Cas No.	4773-96-0
Smiles	OC1=C2C(OC=3C(C2=O)=CC(O)=C(O)C3)=CC(O)=C1[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O
Relative Density.	1.843 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.67 mg/mL (98.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3678 mL	11.8388 mL	23.6776 mL	118.3880 mL
5 mM	0.4736 mL	2.3678 mL	4.7355 mL	23.6776 mL
10 mM	0.2368 mL	1.1839 mL	2.3678 mL	11.8388 mL
20 mM	0.1184 mL	0.5919 mL	1.1839 mL	5.9194 mL
50 mM	0.0474 mL	0.2368 mL	0.4736 mL	2.3678 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc