Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | In stock | $ 118.00 | |
50 μg | 5 days | $ 350.00 | |
500 μg | 5 days | $ 1,520.00 | |
1 mg | 5 days | $ 3,790.00 |
Biological Information |
Immobilized Mouse TGFBR2 -Fc at 10μg/ml (100 μl/well) can bind Mouse/Rat TGF-beta 2*.*: Biotinylated by NHS-biotin prior to testing. The ED50 of Mouse TGFBR2 -Fc is 0.136 ug/ml. (Regularly tested)
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Description | Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
Species | Mouse,Rat |
Expression System | Human Cells |
Tag | None |
Accession Number | P27090 |
Synonyms | transforming growth factor β-2, BSC-1 cell growth inhibitor, G-TSF, TGF-β-2, TGF-beta2, MGC116892, Polyergin, Cetermin, TGF-β2, TGFB2, TGF-beta-2, transforming growth factor beta-2, Glioblastoma-derived T-cell suppressor factor |
Amino Acid | Ala303-Ser414 |
Construction | Recombinant Mouse/Rat Transforming Growth Factor Beta 2 is produced by our Mammalian expression system and the target gene encoding Ala303-Ser414 is expressed. |
Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
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Molecular Weight | 12 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in 4mM HCl. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system. |
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Please read the User Guide of Recombinant Proteins for more specific information.
TGF beta 2 Protein, Mouse/Rat, Recombinant MGC-116892 TGFB 2 transforming growth factor b-2 transforming growth factor β-2 BSC-1 cell growth inhibitor TGFB-2 G-TSF TGF-β-2 TGF-beta2 MGC 116892 MGC116892 Polyergin TGF-b-2 Cetermin TGF-β2 TGFB2 TGF-beta-2 transforming growth factor beta-2 Glioblastoma-derived T-cell suppressor factor recombinant recombinant-proteins proteins protein