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Terconazole

Name: Terconazole
Brand: TargetMol
SKU: T2213
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2213Cas No. 67915-31-5

Alias Triaconazole, Terazol 7, Terazol 3, R42470, Gyno-Terazol

Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.

Terconazole

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Purity: 99.60%

Catalog No. T2213Alias Triaconazole, Terazol 7, Terazol 3, R42470, Gyno-TerazolCas No. 67915-31-5

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	In Stock	In Stock
50 mg	$43	In Stock	In Stock
100 mg	$64	In Stock	In Stock
500 mg	$153	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.60%

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp.
In vitro	Terconazole effectively inhibits the growth of Candida albicans ATCC 44859 in a concentration-dependent manner, demonstrating limited effects at 0.1 to 10 μM when cultured on media promoting the cell form. Its inhibitory impact on yeast cell viability varies across different Candida strains and species. Notably, C. albicans ATCC 44859's susceptibility to terconazole significantly increases on Eagle minimum essential medium, which encourages mycelium formation. The effects of terconazole range from inhibiting mycelia development at 0.1 μM to causing complete necrosis at 100 μM. Moreover, terconazole prevents the morphogenetic shift from the yeast to the filamentous form at concentrations between 0.008 and 0.05 microgram/mL.
In vivo	A three-day, once-daily, intravaginal administration of 0.8% terconazole typically ensures a functional therapeutic duration of seven days, owing to sustained, elevated levels of the biologically active antifungal in the vagina. Terconazole is well-tolerated, with no side effects reported at any concentration[2].
Synonyms	Triaconazole, Terazol 7, Terazol 3, R42470, Gyno-Terazol

Chemical Properties

Molecular Weight	532.46
Formula	C₂₆H₃₁Cl₂N₅O₃
Cas No.	67915-31-5
Smiles	C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)C)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=NC=N5
Relative Density.	1.35g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.87 mg/mL (35.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8781 mL	9.3904 mL	18.7808 mL	93.9038 mL
5 mM	0.3756 mL	1.8781 mL	3.7562 mL	18.7808 mL
10 mM	0.1878 mL	0.9390 mL	1.8781 mL	9.3904 mL
20 mM	0.0939 mL	0.4695 mL	0.9390 mL	4.6952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc