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Harmane
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Catalog No. T3158Cas No. 486-84-0
Alias Loturine, Harman, Aribine
Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.
Harmane
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Purity: 99.96%
Catalog No. T3158Alias Loturine, Harman, AribineCas No. 486-84-0
Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $49 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.96%
Color:White to Yellow
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Product Introduction
Harmane AI Summary
Harmane exhibits a diverse range of bioactivities and has been studied for its effects on various biological targets and systems. It has a binding affinity for the benzodiazepine receptor inverse agonist site in rat cerebral cortical membranes with an IC50 value around 12300 nM, indicating its potential modulatory effect on GABAergic neurotransmission. Furthermore, it inhibits Bufuralol 1'-hydroxylation by human liver microsomes (Ki of 86000 nM) and multiple CDKs, including CDK5 and CDK2, with notable inhibition percentages.
In cancer pharmacology, Harmane shows cytotoxic activity against various cancer cell lines (ED50 ranging from 6.1 to 19.0 µg/ml-1) and against several drug-resistant tumor cell lines, demonstrating potential in overcoming resistance mechanisms. It also displays antiviral activity against HIV1 in human H9 cells (EC50 value of 10700 nM) and against SARS-CoV-2 in VERO-6 cells, among others. Additionally, Harmane exhibits substantial antimalarial activity against both chloroquine-resistant and sensitive Plasmodium falciparum strains, with IC50 values around 7100-12100 nM.
The compound has significant antiplasmodial efficacy, antimicrobial activity against bacteria and fungi, and antiproliferative effects in various human cancer cell lines, albeit with varying degrees of potency. It also demonstrates inhibition of enzymes such as acetylcholinesterase and butyrylcholinesterase, and specific kinases, suggesting a multifaceted inhibitory profile.
In terms of antimicrobial activity, it targets Leishmania stages and Onchocerca volvulus chitinase and shows moderate antibacterial and antifungal properties. Finally, Harmane affects several signaling pathways and receptor activities, such as stimulating insulin secretion activity in rat cells and demonstrating moderate to low binding affinities for various receptors and proteins, indicating a wide spectrum of biological interactions..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke. |
| Targets&IC50 | I1-Imidazoline receptor:30 nM (IC50), 5-HT:101 μM, nAChR:24 μM, benzodiazepine receptor:7 nM, α2-adrenoceptor:18 μM (IC50), MAO-B:5 μM (IC50), MAO-A (human):0.5 μM (IC50), Loperamide:163 μM, Opioid receptor:2.8 μM |
| Synonyms | Loturine, Harman, Aribine |
| Molecular Weight | 182.22 |
| Formula | C12H10N2 |
| Cas No. | 486-84-0 |
| Smiles | Cc1nccc2c3ccccc3[nH]c12 |
| Relative Density. | 1.1485 g/cm3 (Estimated) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (274.39 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.98 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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