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Squalamine lactate

Name: Squalamine lactate
Brand: TargetMol
SKU: T12996
Rating: 4.5 (1 reviews)

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Catalog No. T12996Cas No. 320725-47-1

Alias MSI-1256F

Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.

Squalamine lactate

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Catalog No. T12996Alias MSI-1256FCas No. 320725-47-1

Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,420	10-14 weeks	10-14 weeks
50 mg	$3,180	10-14 weeks	10-14 weeks
100 mg	$4,300	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.
In vitro	Squalamine lactate has a more general effect on the cell signaling cascade, which is common to VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].
In vivo	When administered intravitreally and therefore requires intravenous dosing, Squalamine is ineffective . However, systemic dosing has yielded promising results in rats as well as humans[2].
Synonyms	MSI-1256F

Chemical Properties

Molecular Weight	718.04
Formula	C₃₇H₇₁N₃O₈S
Cas No.	320725-47-1
Smiles	C[C@H](O)C(O)=O.[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)NCCCNCCCCN)[C@H](C)CC[C@@H](OS(O)(=O)=O)C(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36.66 mg/mL (51.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3927 mL	6.9634 mL	13.9268 mL	69.6340 mL
5 mM	0.2785 mL	1.3927 mL	2.7854 mL	13.9268 mL
10 mM	0.1393 mL	0.6963 mL	1.3927 mL	6.9634 mL
20 mM	0.0696 mL	0.3482 mL	0.6963 mL	3.4817 mL
50 mM	0.0279 mL	0.1393 mL	0.2785 mL	1.3927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc