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Squalamine lactate

Name: Squalamine lactate
Brand: TargetMol
SKU: T12996
Rating: 4.5 (1 reviews)

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Catalog No. T12996Cas No. 320725-47-1

Alias MSI-1256F

Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.

Squalamine lactate

😃Good

Catalog No. T12996Alias MSI-1256FCas No. 320725-47-1

Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.

Pack Size	Price	Availability
25 mg	$2,420	10-14 weeks
50 mg	$3,180	10-14 weeks
100 mg	$4,300	10-14 weeks

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Product Introduction

Bioactivity

Description	Squalamine lactate, an aminosterol compound discovered in the tissues of the dogfish shark, exhibits antimicrobial activity.
In vitro	Squalamine lactate has a more general effect on the cell signaling cascade, which is common to VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].
In vivo	When administered intravitreally and therefore requires intravenous dosing, Squalamine is ineffective . However, systemic dosing has yielded promising results in rats as well as humans[2].
Synonyms	MSI-1256F

Chemical Properties

Molecular Weight	718.04
Formula	C₃₇H₇₁N₃O₈S
Cas No.	320725-47-1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36.66 mg/mL (51.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3927 mL	6.9634 mL	13.9268 mL	69.6340 mL
5 mM	0.2785 mL	1.3927 mL	2.7854 mL	13.9268 mL
10 mM	0.1393 mL	0.6963 mL	1.3927 mL	6.9634 mL
20 mM	0.0696 mL	0.3482 mL	0.6963 mL	3.4817 mL
50 mM	0.0279 mL	0.1393 mL	0.2785 mL	1.3927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc