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Anti-DCPLA Antibody (2R679)
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Catalog No. TMAC-01123
Alias Transcription factor SMIF, SMAD4IP1 SMIF, Smad4-interacting transcriptional co-activator, Smad4 interacting transcriptional co activator, Putative protein product of Nbla00360, Nbla00360, mRNA-decapping enzyme 1A, mRNA decapping enzyme 1A, HSA275986, Decapping mRNA 1A, Decapping enzyme hDcp1a, DCP1A_HUMAN, Dcp1a, DCP1 decapping enzyme homolog A
Anti-DCPLA Antibody (2R679) is a Rabbit antibody targeting DCPLA. Anti-DCPLA Antibody (2R679) can be used in FCM,ICC,IHC,WB.
Anti-DCPLA Antibody (2R679)
Anti-DCPLA Antibody (2R679)
😃Good
Catalog No. TMAC-01123Alias Transcription factor SMIF, SMAD4IP1 SMIF, Smad4-interacting transcriptional co-activator, Smad4 interacting transcriptional co activator, Putative protein product of Nbla00360, Nbla00360, mRNA-decapping enzyme 1A, mRNA decapping enzyme 1A, HSA275986, Decapping mRNA 1A, Decapping enzyme hDcp1a, DCP1A_HUMAN, Dcp1a, DCP1 decapping enzyme homolog A
Anti-DCPLA Antibody (2R679) is a Rabbit antibody targeting DCPLA. Anti-DCPLA Antibody (2R679) can be used in FCM,ICC,IHC,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-DCPLA Antibody (2R679) is a Rabbit antibody targeting DCPLA. Anti-DCPLA Antibody (2R679) can be used in FCM,ICC,IHC,WB. |
| Synonyms | Transcription factor SMIF, SMAD4IP1 SMIF, Smad4-interacting transcriptional co-activator, Smad4 interacting transcriptional co activator, Putative protein product of Nbla00360, Nbla00360, mRNA-decapping enzyme 1A, mRNA decapping enzyme 1A, HSA275986, Decapping mRNA 1A, Decapping enzyme hDcp1a, DCP1A_HUMAN, Dcp1a, DCP1 decapping enzyme homolog A |
| Ig Type | IgG |
| Clone | 2R679 |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of Dcp1a on human liver tissue lysates using anti-Dcp1a antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Dcp1a antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Dcp1a antibody. Counter stained with hematoxylin. 4. ICC staining Dcp1a in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Dcp1a in SiHa cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Dcp1a in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of LOVO cells with Dcp1a antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Cleavage of the 5'-cap structure is involved in the major 5'-to-3' and nonsense-mediated mRNA decay pathways. The protein complex consisting of Dcp1 and Dcp2 has been identified as the species responsible for the decapping reaction in Saccharomyces cerevisiae. In nonsense-mediated decay, the human decapping complex, made up of S. cerevisiae homologs Dcp1a and hDcp2, may be recruited to mRNAs containing premature termination codons by nonsense-mediated decay factor (Upf) proteins. hDcp2 specifically hydrolyzes methylated capped RNA to release m(7)GDP, thereby aiding in mRNA degradation. Both Dcp1a and hDcp2 colocalize in the cytoplasm. In addition, Dcp1a interacts with Smad4 forming a complex with TGFβ and BMP-4. Dcp1a and Smad4 interact directly through a EVH1/WH1 domain on Dcp1a and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of Dcp1a as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of Dcp1a eliminates TGFβ-induced nuclear translocation of Dcp1a. |
| Conjucates | Unconjugated |
| Uniprot ID |
| Molecular Weight | Theoretical: 63 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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