ACVR2A Protein, Human, Recombinant (aa 161-513, His)

Catalog No. TMPC-00063 Copy Product Info

ACVR2A Protein, Human, Recombinant (aa 161-513, His) is expressed in Baculovirus-Insect Cells. The accession number is P27037.

ACVR2A Protein, Human, Recombinant (aa 161-513, His)

Catalog No. TMPC-00063

Copy Product Info

ACVR2A Protein, Human, Recombinant (aa 161-513, His) is expressed in Baculovirus-Insect Cells. The accession number is P27037.

Pack Size	Price	USA Stock	Global Stock	Quantity
10 μg	$1,390	35 days	35 days

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of ACVR2A was determined to be 1.5 nmol /min/mg by ADP-Glo kinase assay.
Description	ACVR2A Protein, Human, Recombinant (aa 161-513, His) is expressed in Baculovirus-Insect Cells. The accession number is P27037.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-His
Accession Number	P27037
Synonyms	ACVR2A,ACVR2,ACTR-IIA,ACTRIIA,Activin receptor type-2A,Activin receptor type IIA
Construction	Recombinant human ACVR2A (161-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Protein Purity	>85% as determined by SDS-PAGE.
Molecular Weight	~47 kDa
Formulation	Supplied as sterile 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.