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Minnelide

Name: Minnelide
Brand: TargetMol
SKU: T12042
Rating: 4.5 (1 reviews)

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Synonyms:

Catalog No. T12042 Copy Product Info

Purity: 99.59%

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Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb.

Cas No. 1254702-87-8

Pack Size	Price	USA Stock	Global Stock
2 mg	$569	10-14 weeks	10-14 weeks
5 mg	$918	10-14 weeks	10-14 weeks
10 mg	$1,689	10-14 weeks	10-14 weeks
25 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks
100 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.59%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb.
In vitro	Minnelide (0.100 nM, 200 nM; 48 hours) decreased cell viability in vitro in the pancreatic cancer cell lines S2-013, MIA PaCa-2, S2-VP10, and Panc-1[2].
In vivo	In the orthotopic model of pancreatic cancer with MIA PaCa-2-derived human pancreatic tumors in athymic nude mice, Minnelide (0.1-0.6 mg/kg; intraperitoneal injection; once daily or twice daily) was able to inhibit pancreatic tumor growth in vivo[2].

Chemical Properties

Molecular Weight	514.37
Formula	C₂₁H₂₅Na₂O₁₀P
Cas No.	1254702-87-8
Smiles	C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OCOP([O-])([O-])=O.[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (19.44 mM), Sonication is recommended.

H2O: 80 mg/mL (155.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9441 mL	9.7206 mL	19.4413 mL	97.2063 mL
5 mM	0.3888 mL	1.9441 mL	3.8883 mL	19.4413 mL
10 mM	0.1944 mL	0.9721 mL	1.9441 mL	9.7206 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0972 mL	0.4860 mL	0.9721 mL	4.8603 mL
50 mM	0.0389 mL	0.1944 mL	0.3888 mL	1.9441 mL
100 mM	0.0194 mL	0.0972 mL	0.1944 mL	0.9721 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc