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Hydroxystilbamidine bis(methanesulfonate)

Name: Hydroxystilbamidine bis(methanesulfonate)
Brand: TargetMol
SKU: T19014
Rating: 4.5 (1 reviews)

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Catalog No. T19014Cas No. 223769-64-0

Hydroxystilbamidine bis(methanesulfonate) is a fluorescent cationic dye that binds strongly to DNA and RNA, and is widely used as a retrograde neuronal tracer, while also acting as a potent inhibitor of cellular ribonucleases, making it a versatile research reagent for neuroanatomical tracing, nucleic acid labeling, and studies of RNA stability and degradation.

Hydroxystilbamidine bis(methanesulfonate)

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Catalog No. T19014Cas No. 223769-64-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$693	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Hydroxystilbamidine bis(methanesulfonate) is a fluorescent cationic dye that binds strongly to DNA and RNA, and is widely used as a retrograde neuronal tracer, while also acting as a potent inhibitor of cellular ribonucleases, making it a versatile research reagent for neuroanatomical tracing, nucleic acid labeling, and studies of RNA stability and degradation.
In vitro	The trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) facilitates mRNA recovery following polysome release with Nonidet P-40 (NP-40), as analyzed by sucrose gradient distribution of detergent-lysed postnuclear supernates [1].
In vivo	In mouse models immunized with Sheep Red Blood Cells (SRBC),Hydroxystilbamidine bis(methanesulfonate) has been evaluated for its effects on the immune response. Administration of the compound is associated with a reduction in the count of Plaque-Forming Cells (PFC) [2].

Chemical Properties

Molecular Weight	376.43
Formula	C₁₇H₂₀N₄O₄S
Cas No.	223769-64-0
Smiles	O=S(=O)(O)C.N=C(N)C1=CC=C(C=C1)C=CC2=CC=C(C=C2O)C(=N)N
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (106.26 mM), Sonication is recommended.

DMSO: 40 mg/mL (106.26 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6565 mL	13.2827 mL	26.5654 mL	132.8268 mL
5 mM	0.5313 mL	2.6565 mL	5.3131 mL	26.5654 mL
10 mM	0.2657 mL	1.3283 mL	2.6565 mL	13.2827 mL
20 mM	0.1328 mL	0.6641 mL	1.3283 mL	6.6413 mL
50 mM	0.0531 mL	0.2657 mL	0.5313 mL	2.6565 mL
100 mM	0.0266 mL	0.1328 mL	0.2657 mL	1.3283 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Hydroxystilbamidine bis(methanesulfonate)

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