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Pregnenolone monosulfate sodium

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Catalog No. T16574Cas No. 1852-38-6
Alias 3β-Hydroxy-5-pregnen-20-one monosulfate sodium

Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.

Pregnenolone monosulfate sodium
Other Forms of Pregnenolone monosulfate sodium:
Pregnenolone monosulfateT125361247-64-9
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Pregnenolone monosulfate sodium

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Purity: 99.76%
Catalog No. T16574Alias 3β-Hydroxy-5-pregnen-20-one monosulfate sodiumCas No. 1852-38-6
Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$29In StockIn Stock
25 mg$49In StockIn Stock
50 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.76%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.
In vitro
Pregnenolone monosulfate sodium does not alter agonist binding, but only agonist efficacy. Pregnenolone monosulfate sodium may act as a signal-specific negative allosteric modulator that occupies a site distinct from that occupied by the orthosteric ligand. When slices were pretreated with 100 nM Pregnenolone monosulfate sodium, the effects of THC were significantly attenuated (15.1 ± 1.8% inhibition). These effects may be due to Pregnenolone monosulfate sodium's presynaptic actions. Thus, Pregnenolone monosulfate sodium prevented the THC-induced increase in paired-pulse ratio but did not alter the amplitude or decay time of miniature EPSCs. [1]
In vivo
Pregnenolone monosulfate sodium (2, 4 mg/kg) injected before each dose reduced WIN 55,212-2 intake and lowered breakpoints in a progressive ratio schedule.
Pregnenolone monosulfate sodium (2-6 mg/kg) blocked THC-induced food intake in Wistar rats and C57BL/6N mice and attenuated THC-induced memory impairment in mice, but it did not modify these behaviors by itself [1].
Synonyms3β-Hydroxy-5-pregnen-20-one monosulfate sodium
Chemical Properties
Molecular Weight418.52
FormulaC21H31NaO5S
Cas No.1852-38-6
SmilesC[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OS(=O)([O-])=O)([H])[C@@]4([H])[C@](CC3)([C@H](CC4)C(C)=O)C.[Na+]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (191.15 mM), Sonication is recommended.
H2O: 2 mg/mL (4.78 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.88 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.3894 mL11.9469 mL23.8937 mL119.4686 mL
DMSO
1mg5mg10mg50mg
5 mM0.4779 mL2.3894 mL4.7787 mL23.8937 mL
10 mM0.2389 mL1.1947 mL2.3894 mL11.9469 mL
20 mM0.1195 mL0.5973 mL1.1947 mL5.9734 mL
50 mM0.0478 mL0.2389 mL0.4779 mL2.3894 mL
100 mM0.0239 mL0.1195 mL0.2389 mL1.1947 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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