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VK-2019

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Catalog No. T88923Cas No. 2044520-06-9
Alias VK2019, VK 2019

VK-2019 is a selective inhibitor of Epstein–Barr virus nuclear antigen 1 (EBNA1) that was developed to specifically block EBNA1 DNA-binding activity, and is currently in phase 1 development for the treatment of EBV-associated carcinomas, supporting research into viral episome maintenance, oncogenic persistence, and targeted antiviral cancer therapies.

VK-2019

VK-2019

😃Good
Catalog No. T88923Alias VK2019, VK 2019Cas No. 2044520-06-9
VK-2019 is a selective inhibitor of Epstein–Barr virus nuclear antigen 1 (EBNA1) that was developed to specifically block EBNA1 DNA-binding activity, and is currently in phase 1 development for the treatment of EBV-associated carcinomas, supporting research into viral episome maintenance, oncogenic persistence, and targeted antiviral cancer therapies.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5208-10 weeks8-10 weeks
50 mg$1,9808-10 weeks8-10 weeks
100 mg$2,5008-10 weeks8-10 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
VK-2019 is a selective inhibitor of Epstein–Barr virus nuclear antigen 1 (EBNA1) that was developed to specifically block EBNA1 DNA-binding activity, and is currently in phase 1 development for the treatment of EBV-associated carcinomas, supporting research into viral episome maintenance, oncogenic persistence, and targeted antiviral cancer therapies.
In vivo
In preclinical xenograft models of EBV-positive NPC, oral administration of VK-2019 results in tumor growth inhibition. The compound exhibits oral bioavailability and metabolic stability in animal models, reaching plasma concentrations sufficient to drive antitumor effects [1].
SynonymsVK2019, VK 2019
Chemical Properties
Molecular Weight451.51
FormulaC29H25NO4
Cas No.2044520-06-9
SmilesO=C(O)C=1C=CC=C(C#CC2=CC=C(C=C2)COC3CCOCC3)C1C=4C=CC=5C=CNC5C4
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (177.18 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2148 mL11.0740 mL22.1479 mL110.7395 mL
5 mM0.4430 mL2.2148 mL4.4296 mL22.1479 mL
10 mM0.2215 mL1.1074 mL2.2148 mL11.0740 mL
20 mM0.1107 mL0.5537 mL1.1074 mL5.5370 mL
50 mM0.0443 mL0.2215 mL0.4430 mL2.2148 mL
100 mM0.0221 mL0.1107 mL0.2215 mL1.1074 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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