Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Silvestrol

Name: Silvestrol
Brand: TargetMol
SKU: T16884
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T16884Cas No. 697235-38-4

Alias (-)-Silvestrol

Silvestrol, a eukaryotic translation initiation factor 4A inhibitor, induces autophagy and caspase-mediated apoptosis.

Silvestrol

Copy Product Info

😃Good

Catalog No. T16884Alias (-)-SilvestrolCas No. 697235-38-4

Silvestrol, a eukaryotic translation initiation factor 4A inhibitor, induces autophagy and caspase-mediated apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks
100 mg	Inquiry	10-14 weeks	10-14 weeks

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Silvestrol, a eukaryotic translation initiation factor 4A inhibitor, induces autophagy and caspase-mediated apoptosis.
In vitro	Silvestrol shows significant cytotoxic activity against many human cancer cell lines, such as lung, prostate, and breast cancer (IC50: ranging from 1 to 7 nM). Silvestrol significantly reduces the number of LNCaP cell colonies. Silvestrol-mediated cell death is attenuated in ATG7-null mouse embryonic fibroblasts lacking a functional autophagy protein. Silvestrol induces caspase-3 activation and apoptotic cell death in a time- and dose-dependent manner. Silvestrol and episilvestrol show synergistic effects in combination with CDDP. Silvestrol (30 nM, 120 nM) induces apoptosis in LNCaP cells, through the mitochondrial pathway. Silvestrol (50 nM) exerts an immediate inhibitory effect and causes near-static cell index compared with the control cells. Silvestrol (6.25 nM) enhances proliferation more than the vehicle control-treated cells, whereas a higher concentration of Silvestrol (50 nM) can inhibit cell proliferation [1][2][3][4].
In vivo	Silvestrol significantly prolongs survival compared to vehicle. Silvestrol (1.5 mg/kg, i.p.) does not adversely affect the production of human IgG by xenografted B-lymphocytes in mice [5].
Synonyms	(-)-Silvestrol

Chemical Properties

Molecular Weight	654.66
Formula	C₃₄H₃₈O₁₃
Cas No.	697235-38-4
Smiles	CO[C@@H]1OC[C@@H](O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1)[C@H](O)CO
Relative Density.	1.45 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 6.6 mg/mL (10.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5275 mL	7.6376 mL	15.2751 mL	76.3755 mL
5 mM	0.3055 mL	1.5275 mL	3.0550 mL	15.2751 mL
10 mM	0.1528 mL	0.7638 mL	1.5275 mL	7.6376 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc