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MK 0893

Name: MK 0893
Brand: TargetMol
SKU: T12055
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T12055Cas No. 870823-12-4

MK 0893 is a potent, selective antagonist of glucagon receptor.

MK 0893

😃Good

Catalog No. T12055Cas No. 870823-12-4

MK 0893 is a potent, selective antagonist of glucagon receptor.

Pack Size	Price	Availability
25 mg	$1,870	8-10 weeks
50 mg	$2,768	8-10 weeks
100 mg	$4,950	8-10 weeks

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	MK 0893 is a potent, selective antagonist of glucagon receptor.
Targets&IC50	Glucagon receptor:6.6 nM
In vitro	MK 0893 is active against the rhesus monkey GCGR(IC50 of 56 nM in a cAMP assay with CHO cells expressing the rhesus GCGR)[1].
In vivo	In hGCGR mice on a high fat diet, MK 0893 at 3, and 10 mpk po in feed lowers blood glucose levels by 89% and 94% at day 10, respectively, relative to the difference between the vehicle control and lean hGCGR mice[1].

Chemical Properties

Molecular Weight	588.48
Formula	C₃₂H₂₇Cl₂N₃O₄
Cas No.	870823-12-4
Smiles	COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1
Relative Density.	1.33

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.33 mg/mL (56.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6993 mL	8.4965 mL	16.9929 mL	84.9647 mL
5 mM	0.3399 mL	1.6993 mL	3.3986 mL	16.9929 mL
10 mM	0.1699 mL	0.8496 mL	1.6993 mL	8.4965 mL
20 mM	0.0850 mL	0.4248 mL	0.8496 mL	4.2482 mL
50 mM	0.0340 mL	0.1699 mL	0.3399 mL	1.6993 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MK-0893MK0893MK 0893