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(1S,3R,5R)-PIM447 dihydrochloride

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Catalog No. T13425
Alias (1S,3R,5R)-LGH447 dihydrochloride

(1S,3R,5R)-PIM447 (dihydrochloride) is an inhibitor of PIM with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2, and 0.369 μM for Pim3.

(1S,3R,5R)-PIM447 dihydrochloride
Other Forms of (1S,3R,5R)-PIM447 dihydrochloride:

(1S,3R,5R)-PIM447 dihydrochloride

😃Good
Catalog No. T13425Alias (1S,3R,5R)-LGH447 dihydrochloride
(1S,3R,5R)-PIM447 (dihydrochloride) is an inhibitor of PIM with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2, and 0.369 μM for Pim3.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$2,4203-6 months3-6 months
50 mg$3,1803-6 months3-6 months
100 mg$4,3003-6 months3-6 months
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
(1S,3R,5R)-PIM447 (dihydrochloride) is an inhibitor of PIM with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2, and 0.369 μM for Pim3.
Targets&IC50
Pim1:0.095 μM , Pim1:0.369 μM , Pim1:0.52 μM
Synonyms(1S,3R,5R)-LGH447 dihydrochloride
Chemical Properties
Molecular Weight513.38
FormulaC24H25Cl2F3N4O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 33.33 mg/mL (64.92 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.9 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9479 mL9.7394 mL19.4787 mL97.3937 mL
5 mM0.3896 mL1.9479 mL3.8957 mL19.4787 mL
10 mM0.1948 mL0.9739 mL1.9479 mL9.7394 mL
20 mM0.0974 mL0.4870 mL0.9739 mL4.8697 mL
50 mM0.0390 mL0.1948 mL0.3896 mL1.9479 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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