HLA-A*02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein, Human, MHC (His & Avi)

Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.

Pack Size	Availability	Price/USD	Quantity
100 μg	Inquiry	$ 489.00
1 mg	Inquiry	$ 3,265.00

Pack Size

Availability

Price/USD

Quantity

100 μg

Inquiry

$ 489.00

1 mg

Inquiry

$ 3,265.00

Description

Species	Human
Expression System	HEK293
Tag	C-His-Avi
Accession Number	AAA03604.1(HLA-A*02:03)&P61769(B2M)&FMNKFIYEI
Synonyms	MHC, AFPD, Alpha-fetoprotein, FETA, Alpha-1-fetoprotein, AFP, HPAFP, Alpha-feto
Construction	Recombinant Human HLA-A02:03&B2M&AFP (FMNKFIYEI) Tetramer Protein is expressed from HEK293 His tag and Avi tag at the C-Terminus, tetramer is assembled by biotinylated monomer and streptavidin. It contains Gly25-Thr305(HLA-A02:03),Ile21-Met119(B2M) and FMNKFIYEI peptide.[Accession \|AAA03604.1(HLA-A*02:03)&P61769(B2M)&FMNKFIYEI]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt.-20 to -80°C for 3-6 months in unopened state after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Alpha-fetoprotein (AFP), a specific liver cancer marker, T cells expressing AFP-CAR selectively degranulated, released cytokines, and lysed liver cancer cells that were HLA-A*02:01 /AFP while sparing cells from multiple tissue types that were negative for either expressed proteins.CAR T-cell immunotherapy targeting intracellular/secreted solid tumor antigens can elicit a potent antitumor response.