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ANP(1-28) Acetate (human, porcine)

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Catalog No. TP1220L
Alias Carperitide acetate (89213-87-6 Free base), Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compound effectively inhibits the secretion of endothelin-1 in a dose-dependent manner.

ANP(1-28) Acetate (human, porcine)
Other Forms of ANP(1-28) Acetate (human, porcine):
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine AcetateTP12191366000-58-9
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ANP(1-28) Acetate (human, porcine)

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Purity: 98.24%
Catalog No. TP1220LAlias Carperitide acetate (89213-87-6 Free base), Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compound effectively inhibits the secretion of endothelin-1 in a dose-dependent manner.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195In StockIn Stock
5 mg$483In StockIn Stock
10 mg$691In StockIn Stock
25 mg$1,080In StockIn Stock
50 mg$1,460In StockIn Stock
100 mg$1,970-In Stock
200 mg$2,660-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:98.24%
Appearance:Solid
Color:White
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COA HPLC

Product Introduction

Bioactivity
Description
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate), a 28-amino acid hormone, is naturally produced and released by the human heart upon cardiac injury or mechanical stretch. This compound effectively inhibits the secretion of endothelin-1 in a dose-dependent manner.
In vitro
Atrial natriuretic peptide (ANP), isolated from mammalian hearts, exhibits diuretic, natriuretic, and vasodilatory properties. It has been observed that porcine ANP (1-28) not only inhibits the secretion of immunoreactive endothelin-1 in porcine endothelial cells and aorta upon stimulation with Angiotensin II (Ang II) but also elevates cellular cGMP levels. Similarly, human ANP (1-28) suppresses immunoreactive endothelin-1 secretion and enhances cyclic GMP in human umbilical-vein endothelial cells when stimulated by angiotensin II (ANGII) and thrombin. Moreover, in normal rat glomeruli, Human 125I-ANP (1-28) binds to high-affinity receptors, significantly increasing cGMP without affecting cAMP, showcasing its integral role in electrolyte and fluid homeostasis[1,2,3].
SynonymsCarperitide acetate (89213-87-6 Free base), Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
Chemical Properties
Molecular Weight3140.5
FormulaC129H207N45O41S3
SmilesC(C)(O)=O.[C@H](CC1=CC=CC=C1)(C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(O)=O)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@@H](NC(=O)[C@@H]3CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CO)=O)CO)=O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N3)[H])CC(N)=O)=O)CO)=O
Relative Density.no data available
SequenceSer-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
Sequence ShortSLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge: Cys7-Cys23)
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 240 mg/mL (76.42 mM)
H2O: 100 mg/mL (31.84 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM0.3184 mL1.5921 mL3.1842 mL15.9210 mL
5 mM0.0637 mL0.3184 mL0.6368 mL3.1842 mL
10 mM0.0318 mL0.1592 mL0.3184 mL1.5921 mL
20 mM0.0159 mL0.0796 mL0.1592 mL0.7961 mL
DMSO
1mg5mg10mg50mg
50 mM0.0064 mL0.0318 mL0.0637 mL0.3184 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EndothelinReceptorEndothelin ReceptorCarperitide Acetate89213-87-6 Free base89213-87-6
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