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LY2979165

Name: LY2979165
Brand: TargetMol
SKU: T15812
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15812Cas No. 1311385-32-6

Alias mGlu2 agonist

LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.

LY2979165

🥰Excellent

Purity: 98.41%

Catalog No. T15812Alias mGlu2 agonistCas No. 1311385-32-6

LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$156	In Stock
10 mg	$239	In Stock
25 mg	$395	In Stock
50 mg	$588	In Stock
100 mg	$838	In Stock

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Batch Information

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Purity:98.41%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
In vivo	LY2979165 reduces BOLD signal and increases plasma levels of 2812223 in vivo[1].
Synonyms	mGlu2 agonist

Chemical Properties

Molecular Weight	390.42
Formula	C₁₃H₂₂N₆O₆S
Cas No.	1311385-32-6
Smiles	N.O.C[C@H](N)C(=O)N[C@]1(C[C@@H](Sc2ncn[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (102.45 mM), Sonication is recommended.

DMSO: 1 mg/mL (2.56 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5613 mL	12.8067 mL	25.6134 mL	128.0672 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.5123 mL	2.5613 mL	5.1227 mL	25.6134 mL
10 mM	0.2561 mL	1.2807 mL	2.5613 mL	12.8067 mL
20 mM	0.1281 mL	0.6403 mL	1.2807 mL	6.4034 mL
50 mM	0.0512 mL	0.2561 mL	0.5123 mL	2.5613 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	1.2807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc