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LY2979165

Name: LY2979165
Brand: TargetMol
SKU: T15812
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15812Cas No. 1311385-32-6

Alias mGlu2 agonist

LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.

LY2979165

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Purity: 98.41%

Catalog No. T15812Alias mGlu2 agonistCas No. 1311385-32-6

LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$156	-	In Stock
10 mg	$239	-	In Stock
25 mg	$395	-	In Stock
50 mg	$588	-	In Stock
100 mg	$838	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.41%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
In vivo	LY2979165 reduces BOLD signal and increases plasma levels of 2812223 in vivo[1].
Synonyms	mGlu2 agonist

Chemical Properties

Molecular Weight	390.42
Formula	C₁₃H₂₂N₆O₆S
Cas No.	1311385-32-6
Smiles	N.O.C[C@H](N)C(=O)N[C@]1(C[C@@H](Sc2ncn[nH]2)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 40 mg/mL (102.45 mM), Sonication is recommended.

DMSO: 1 mg/mL (2.56 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5613 mL	12.8067 mL	25.6134 mL	128.0672 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.5123 mL	2.5613 mL	5.1227 mL	25.6134 mL
10 mM	0.2561 mL	1.2807 mL	2.5613 mL	12.8067 mL
20 mM	0.1281 mL	0.6403 mL	1.2807 mL	6.4034 mL
50 mM	0.0512 mL	0.2561 mL	0.5123 mL	2.5613 mL
100 mM	0.0256 mL	0.1281 mL	0.2561 mL	1.2807 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc