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Xamoterol hemifumarate

Name: Xamoterol hemifumarate
Brand: TargetMol
SKU: T23536
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23536Cas No. 73210-73-8

Alias ICI 118587 hemifumarate, Corwin hemifumarate

Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr.

Xamoterol hemifumarate

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Purity: 99.79%

Catalog No. T23536Alias ICI 118587 hemifumarate, Corwin hemifumarateCas No. 73210-73-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$158	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$538	In Stock	In Stock
100 mg	$859	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Xamoterol hemifumarate AI Summary

Xamoterol hemifumarate is a versatile bioactive agent exhibiting a broad spectrum of inhibitory and modulatory effects across various biological systems. It is a potent inhibitor of the Menin-MLL interaction relevant in MLL-related leukemias (35481.3 nM), a modulator of Lamin A splicing (8912.5 nM), and an inhibitor of Tau fibril formation (281.8 nM). Additionally, it inhibits Bloom's syndrome helicase (BLM) with a potency of 562.3 nM and demonstrates inhibition against histone lysine methyltransferase G9a (70794.6 nM). Notably, it inhibits Marburg virus binding or entry into cells at a potency of 56.2 nM. In SARS-CoV-2 assays, Xamoterol hemifumarate has an inhibition index of 0.4021 for cell viability in Vero E6 cells. Its effect on cell viability varies among cell types: positive in HEK293T cells (growth rates: 0.64 to 0.95), mixed in U2OS cells (growth rates: 0.31 to -1.0), and negative in human fibroblasts (growth rates: -0.01 to -0.24). The compound also influences protein stability differently across various domains, as shown by thermal shift assays, with Delta TM values ranging from stabilizing (0.09 C to 0.26 C) to destabilizing (-0.01 C to -2.12 C) effects. Furthermore, Xamoterol hemifumarate modulates GPCR signaling pathways, featuring multiple inhibitory actions across several GPCR targets (e.g., GLP1R, AGTR1, CX3CR1, ADRB2) with inhibition ranging from -5.96% to -85.67%, and a stimulating effect on ADGRF1 (%Max 29.7%). These diverse activities suggest its potential in modulating various signaling pathways and therapeutic targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr.
Synonyms	ICI 118587 hemifumarate, Corwin hemifumarate

Chemical Properties

Molecular Weight	794.37
Formula	C₃₆H₅₄N₆O₁₄
Cas No.	73210-73-8
Smiles	OC(/C=C/C(O)=O)=O.OC(C=C1)=CC=C1OCC(O)CNCCNC(N2CCOCC2)=O.OC(C=C3)=CC=C3OCC(O)CNCCNC(N4CCOCC4)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (100.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2589 mL	6.2943 mL	12.5886 mL	62.9430 mL
5 mM	0.2518 mL	1.2589 mL	2.5177 mL	12.5886 mL
10 mM	0.1259 mL	0.6294 mL	1.2589 mL	6.2943 mL
20 mM	0.0629 mL	0.3147 mL	0.6294 mL	3.1471 mL
50 mM	0.0252 mL	0.1259 mL	0.2518 mL	1.2589 mL
100 mM	0.0126 mL	0.0629 mL	0.1259 mL	0.6294 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc