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N1-Methylpseudouridine-5′-triphosphate trisodium

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Catalog No. T73737

N1-Methylpseudouridine-5'-triphosphate trisodium is a modified NTP that can be incorporated into messenger RNA (mRNA) by enzymes like T7 RNA polymerase.

N1-Methylpseudouridine-5′-triphosphate trisodium
Other Forms of N1-Methylpseudouridine-5′-triphosphate trisodium:

N1-Methylpseudouridine-5′-triphosphate trisodium

😃Good
Catalog No. T73737
N1-Methylpseudouridine-5'-triphosphate trisodium is a modified NTP that can be incorporated into messenger RNA (mRNA) by enzymes like T7 RNA polymerase.
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Product Introduction

Bioactivity
Description
N1-Methylpseudouridine-5'-triphosphate trisodium is a modified NTP that can be incorporated into messenger RNA (mRNA) by enzymes like T7 RNA polymerase.
In vitro
N1-Methylpseudouridine-5'-triphosphate trisodium(1 μg, 24 h) incorporated mRNA provides enhanced protein expression and reduced immunogenicity in mammalian cell lines. [1]
In vivo
In mice, mRNA modified with N1-Methylpseudouridine-5'-triphosphate trisodium has a higher ability to translate. [1]
Chemical Properties
Molecular Weight564.11
FormulaC10H14N2Na3O15P3
Smiles#N/A
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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