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2,3-Dibromomaleinimide

Name: 2,3-Dibromomaleinimide
Brand: TargetMol
SKU: TN7161
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7161Cas No. 1122-10-7

Alias 3,4-Dibromopyrrole-2,5-dione, 3,4-dibromo-1h-pyrrole-2,5-dione

2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) is a marine derived natural products found in Axinella brevistyla.

2,3-Dibromomaleinimide

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Purity: 99.57%

Catalog No. TN7161Alias 3,4-Dibromopyrrole-2,5-dione, 3,4-dibromo-1h-pyrrole-2,5-dioneCas No. 1122-10-7

2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) is a marine derived natural products found in Axinella brevistyla.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$30	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

2,3-Dibromomaleinimide AI Summary

2,3-Dibromomaleinimide has demonstrated significant cytotoxicity against various cell lines, specifically mouse L1210 cells with an IC50 value of 0.66 µg/mL and 2580.0 nM, and HEK293 cells with a CC50 value of 3284.0 nM. It exhibits bioactivity related to the inhibition of the AcrAB-TolC efflux pump in Escherichia coli, enhancing the effectiveness of several antibiotics, such as chloramphenicol, tetracycline, piperacillin, levofloxacin, kanamycin, erythromycin, and ciprofloxacin, through modulation of efflux pump mechanisms. Despite its notable antimicrobial potentiation effects in E. coli, the compound does not exhibit direct antibacterial activity against multiple bacterial pathogens including E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Pseudomonas aeruginosa PAO397, and Staphylococcus aureus MRSA at concentrations up to 20,000 nM. Moreover, 2,3-Dibromomaleinimide shows antifungal activity against Candida albicans and Cryptococcus neoformans with MIC values of 20,000 nM and 10,000 nM, respectively. Importantly, it does not cause hemolysis of human red blood cells at concentrations exceeding 20.0 µM, indicating a level of safety in hemolytic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) is a marine derived natural products found in Axinella brevistyla.
Synonyms	3,4-Dibromopyrrole-2,5-dione, 3,4-dibromo-1h-pyrrole-2,5-dione

Chemical Properties

Molecular Weight	254.86
Formula	C₄HBr₂NO₂
Cas No.	1122-10-7
Smiles	BrC1=C(Br)C(=O)NC1=O

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (196.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9237 mL	19.6186 mL	39.2372 mL	196.1861 mL
5 mM	0.7847 mL	3.9237 mL	7.8474 mL	39.2372 mL
10 mM	0.3924 mL	1.9619 mL	3.9237 mL	19.6186 mL
20 mM	0.1962 mL	0.9809 mL	1.9619 mL	9.8093 mL
50 mM	0.0785 mL	0.3924 mL	0.7847 mL	3.9237 mL
100 mM	0.0392 mL	0.1962 mL	0.3924 mL	1.9619 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc