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EGCG Octaacetate

Name: EGCG Octaacetate
Brand: TargetMol
SKU: T8160
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8160Cas No. 148707-39-5

EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.

EGCG Octaacetate

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Purity: 99.25%

Catalog No. T8160Cas No. 148707-39-5

EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	-	In Stock
5 mg	$80	-	In Stock
10 mg	$115	-	In Stock
25 mg	$189	-	In Stock
50 mg	$279	-	In Stock
1 mL x 10 mM (in DMSO)	$130	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.25%

Color:White

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COA

Product Introduction

EGCG Octaacetate AI Summary

EGCG Octaacetate demonstrates multifaceted bioactivities, including inhibition of the chymotrypsin-like activity of the 20S proteasome at 50 µM with an inhibition rate of less than 20%. It exhibits antiviral properties against Influenza A/PR8/34(H1N1) in dog MDCK cells with an EC50 of 77000 nM and against Influenza A/PR8/34(H1N1) with an EC50 of 8490 nM. The compound also shows antiproliferative effects against human MDA-MB-231 cells, with no significant growth inhibition at 25 to 50 µM after 24 hours unless the cells have high catechol-O-methyltransferase (COMT) activity, where it achieves a 42% inhibition at 25 µM. Notably, the antiproliferative effect is enhanced to 89% in the presence of a COMT inhibitor, 3,5-dinitrocatechol, at the same concentration. Furthermore, EGCG Octaacetate induces AMPKalpha phosphorylation in human MDA-MB-231 cells at 20 µM after 3 hours, showing a fold change of 3.9 relative to control, which is associated with regulation of energy metabolism, cell growth, and autophagy. The compound exhibits minimal inhibition (0.5%) of rat liver microsomal Steroid 5-alpha-reductase at 5 µM after 30 minutes. Additionally, it demonstrates cytotoxicity against human LCC-6 cells, human MDA435/LCC6MDR cells, and mouse L929 cells with modulation of P-glycoprotein (P-gp) in human MDA435/LCC6MDR cells leading to the reversal of paclitaxel resistance. This is evidenced by the reduction of paclitaxel IC50 from 152.5 ± 9.7 µM to 176.1 nM after 5 days, indicating significant improvement in paclitaxel sensitivity in these resistant cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.

Chemical Properties

Molecular Weight	794.67
Formula	C₃₈H₃₄O₁₉
Cas No.	148707-39-5
Smiles	CC(=O)Oc1cc(OC(C)=O)c2C[C@@H](OC(=O)c3cc(OC(C)=O)c(OC(C)=O)c(OC(C)=O)c3)[C@H](Oc2c1)c1cc(OC(C)=O)c(OC(C)=O)c(OC(C)=O)c1
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (34.61 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (2.52 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2584 mL	6.2919 mL	12.5838 mL	62.9192 mL
5 mM	0.2517 mL	1.2584 mL	2.5168 mL	12.5838 mL
10 mM	0.1258 mL	0.6292 mL	1.2584 mL	6.2919 mL
20 mM	0.0629 mL	0.3146 mL	0.6292 mL	3.1460 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc