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VT104
🥰Excellent
Catalog No. T67872Cas No. 2417718-25-1
VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research. VT104 blocks palmitoylation of endogenous TEAD1 and TEAD3 proteins.
VT104
🥰Excellent
Purity: 99.5%
Catalog No. T67872Cas No. 2417718-25-1
VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research. VT104 blocks palmitoylation of endogenous TEAD1 and TEAD3 proteins.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $72 | In Stock | In Stock | |
| 5 mg | $158 | In Stock | In Stock | |
| 10 mg | $248 | In Stock | In Stock | |
| 25 mg | $397 | In Stock | In Stock | |
| 50 mg | $569 | In Stock | In Stock | |
| 100 mg | $786 | - | In Stock | |
| 200 mg | $1,090 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $176 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.5%
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Product Introduction
Bioactivity
Chemical Properties
| Description | VT104 is a potent and orally active YAP/TAZ inhibitor for cancer research. VT104 blocks palmitoylation of endogenous TEAD1 and TEAD3 proteins. |
| In vitro | METHODS: Huh7 cells were treated with the pan-TEAD inhibitor VT104 (0.1, 0.5, 1, 2.5, 5 μM) for 72 h and then subjected to WST assay to assess cell number or 24 h for qPCR of ANKRD1, ANLN, and KIF23. RESULTS VT104 reduced Huh7 cell proliferation and inhibited the TAZ-TEAD pathway, with reduced expression of TAZ-TEAD targets ANLN, KIF23, ANKRD1, CTGF, and CD274 in Huh7 cells. [3] |
| In vivo | METHODS: Mice after MET+CTNNB1-S45Y HTVI were treated with VT104 (10 mg/kg/day) for 6 weeks. RESULTS VT104 strongly inhibited HCC development in vivo driven by MET+CTNNB1-S45Y; VT104 significantly reduced Ki67+ proliferation and γH2AX-positive hepatocytes. [3] |
| Molecular Weight | 420.43 |
| Formula | C25H19F3N2O |
| Cas No. | 2417718-25-1 |
| Smiles | C[C@H](NC(=O)c1ccc2c(cccc2c1)-c1ccc(cc1)C(F)(F)F)c1ccccn1 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (71.36 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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