Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 255.00 | |
10 mg | In stock | $ 416.00 | |
25 mg | In stock | $ 673.00 | |
50 mg | In stock | $ 947.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 279.00 |
Description | VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins. |
In vitro | VT104 is a pan-TEAD binder, with low nanomolar IC50 values in proliferation assays using YAP1/TEAD-dependent cell lines [1]. |
In vivo | VT104 also exhibits a favorable pharmacokinetics profile with exposure sufficient for daily dosing in mice. In the NCI-H226 xenograft efficacy model, VT-104 is highly active with a TGI = 102% at 3 mg/kg PO [1]. |
Molecular Weight | 420.43 |
Formula | C25H19F3N2O |
CAS No. | 2417718-25-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (71.35 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
VT104 2417718-25-1 Stem Cells YAP inhibitor inhibit