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TC-N 22A

🥰Excellent
Catalog No. T23440Cas No. 1314140-00-5

TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 μM). TC-N 22A can be used in the study of central nervous system diseases.

TC-N 22A

TC-N 22A

🥰Excellent
Purity: 99.95%
Catalog No. T23440Cas No. 1314140-00-5
TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 μM). TC-N 22A can be used in the study of central nervous system diseases.
Pack SizePriceAvailabilityQuantity
1 mg$123In Stock
5 mg$263In Stock
10 mg$325In Stock
25 mg$548In Stock
50 mg$788In Stock
100 mg$1,080In Stock
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Purity:99.95%
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COA LCMS HPLC HNMR

Product Introduction

Bioactivity
Description
TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 μM). TC-N 22A can be used in the study of central nervous system diseases.
Targets&IC50
mGlu4 receptor:9 nM (EC50), mGlu1/2/3/5/7 receptors:>10 μM (EC50)
Chemical Properties
Molecular Weight283.35
FormulaC14H13N5S
Cas No.1314140-00-5
SmilesN(C1=NC=2C=3C(=NNC3)CCCC2S1)C4=CC=CC=N4
Relative Density.1.435 g/cm3 (Predicted)
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (176.46 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5292 mL17.6460 mL35.2920 mL176.4602 mL
5 mM0.7058 mL3.5292 mL7.0584 mL35.2920 mL
10 mM0.3529 mL1.7646 mL3.5292 mL17.6460 mL
20 mM0.1765 mL0.8823 mL1.7646 mL8.8230 mL
50 mM0.0706 mL0.3529 mL0.7058 mL3.5292 mL
100 mM0.0353 mL0.1765 mL0.3529 mL1.7646 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

TC-N 22ATCN 22ATC N 22AmGluR4
Related Tags: buy TC-N 22A | purchase TC-N 22A | TC-N 22A cost | order TC-N 22A | TC-N 22A chemical structure | TC-N 22A formula | TC-N 22A molecular weight
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