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HHQ

Name: HHQ
Brand: TargetMol
SKU: T19713
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19713Cas No. 40522-46-1

Alias 2-heptylquinolin-4(1H)-one

HHQ (2-heptylquinolin-4(1H)-one) is a PqsR antagonist.

HHQ

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Purity: 99.46%

Catalog No. T19713Alias 2-heptylquinolin-4(1H)-oneCas No. 40522-46-1

HHQ (2-heptylquinolin-4(1H)-one) is a PqsR antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$55	In Stock	In Stock
5 mg	$90	In Stock	In Stock
10 mg	$146	In Stock	In Stock
25 mg	$245	In Stock	In Stock
50 mg	$363	In Stock	In Stock
100 mg	$538	-	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.46%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR LCMS

Product Introduction

HHQ AI Summary

HHQ shows significant bioactivity related to the inhibition of Plasmodium falciparum, a malaria-causing parasite, demonstrated through its high inhibition percentages against various strains in whole erythrocytes. This compound inhibits the LDH activity of the parasite and has moderate inhibitory effects on the HepG2 human cell line. It exhibits antiplasmodial activity against both chloroquine/mefloquine-resistant Dd2 and chloroquine-sensitive 3D7 strains of Plasmodium falciparum, with IC50 values of 1315.0 nM and 1356.0 nM, respectively. Its selectivity ratio indicates a potential preference for targeting malaria parasites over human cells. Additionally, HHQ demonstrates cytotoxicity against transgenic Leishmania Mexicana promastigotes, with varied inhibition levels based on glucose transporter complementation. It also possesses high aqueous solubility at 15000.0 nM and shows agonist activity at Pseudomonas aeruginosa PqsR, inducing transcriptional activity. This highlights the compound's broad spectrum of bioactivity and its potential as an antimalarial and antiparasitic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	HHQ (2-heptylquinolin-4(1H)-one) is a PqsR antagonist.
Synonyms	2-heptylquinolin-4(1H)-one

Chemical Properties

Molecular Weight	243.34
Formula	C₁₆H₂₁NO
Cas No.	40522-46-1
Smiles	CCCCCCCc1cc(=O)c2ccccc2[nH]1
Relative Density.	1.013 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (102.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1095 mL	20.5474 mL	41.0948 mL	205.4738 mL
5 mM	0.8219 mL	4.1095 mL	8.2190 mL	41.0948 mL
10 mM	0.4109 mL	2.0547 mL	4.1095 mL	20.5474 mL
20 mM	0.2055 mL	1.0274 mL	2.0547 mL	10.2737 mL
50 mM	0.0822 mL	0.4109 mL	0.8219 mL	4.1095 mL
100 mM	0.0411 mL	0.2055 mL	0.4109 mL	2.0547 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PqsRHHQ

HHQ

HHQ

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