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PAK4-IN-2

Catalog No. T61299 CAS 2488706-33-6

PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant potential in cancer research [1].

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PAK4-IN-2, CAS 2488706-33-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description

In vitro

PAK4-IN-2 (compound 5n) demonstrated significant inhibition of cell growth within a 72-hour treatment across various concentrations (0-10 μM) in the hematoma tumor cell line MV4-11 and the solid tumor cell line MDA-MB-231, with reduced effects in normal human renal epithelial cells (239T). At lower concentrations (5-50 nM) over 48 hours, it predominantly arrested cells in the G0/G1 phase, reducing the S-phase population. Further, PAK4-IN-2 induced apoptosis in MV4-11 cells in a dose-dependent manner with concentrations ranging from 10 to 250 nM over 48 hours. Additionally, a marked concentration-dependent reduction in p-PAK4(Ser474) expression levels was observed in MV4-11 cells treated with 50 to 800 nM of PAK4-IN-2 for 24 hours. The compound’s potency was quantified in cell proliferation assays, revealing a notable anti-proliferative effect in MV4-11 (IC50 = 7.8 ± 2.8 nM) and a moderate effect in MDA-MB-231 cells (IC50 = 825 ± 106 nM), with minimal sensitivity in 239T cells (IC50 > 10000 nM).

Molecular Weight	356.85
Formula	C18H21ClN6
CAS No.	2488706-33-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PAK4-IN-2 2488706-33-6 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.